Abstract
Summary
Phospholipase C and pancreatic lipase reduce the reabsorption of fluid droplets infused into rat proximal tubules. Phospholipase D, chymotrypsin, hyaluronidase, collagenase and CaCl2 appeared to have no effect on reabsorption rate. Ribonuclease also reduced fluid reabsorption. When kidney ho-mogenates are treated with the same enzymes, phospholipase C and chymotrypsin reduce the ability of extractable phospholipids to bind sodium and potassium. The data suggest that phospholipase D and ribonuclease may enhance cation binding. It is suggested that phospholipids play a critical role in salt transport by the proximal tubule.
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