Abstract
Summary
1) Urinary excretions of PGA and CF were estimated in patients suffering from cirrhosis of liver, typhoid fever, renal hypertension, essential hypertension, acute malaria, influenza, tuberculosis, nutritional anemia and in normal subjects. They were also studied after administration of PGA by both enteral and intravenous routes, with or without simultaneous administration of ascorbic acid. Patients suffering from cirrhosis of liver, typhoid fever, renal hypertension, acute malaria, influenza and nutritional anemia excreted diminished amounts of PGA and CF than normal persons. After feeding of PGA patients suffering from above diseases excreted less CF than normal persons under similar conditions. These excretions in patients suffering from essential hypertension and tuberculosis were similar to excretions by normal persons. Administration of ascorbic acid along with PGA enhanced urinary excretion of CF in all diseased conditions but the increase was less than that observed in normal subjects. Intravenous injection of PGA increased the output of PGA in urine but excretion of CF was similar to excretions observed after feeding PGA. 2) Different tissues of the body seem to be concerned in conversion of PGA to CF in the body and administration of PGA or CF in different diseased conditions is suggested.
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