The design of an efficient controller for a process of batch crystallization is still an important area of ongoing research. In this paper, a
-variable adaptive model-free control (
-AMFC) has been proposed to control a seeded batch adipic acid crystallization process to get a final unimodal crystal size distribution (CSD) within the required mean weight size. The
-AMFC is developed based on
online adaptive estimation algorithm to enhance the classic model-free control’s (MFC) performance. It copes with unknown as well as partially known dynamics and the inherent complex behavior of this nonlinear process. The concept consists of using an updated local approximation model. Two structures of
-AMFC are considered. The first is a
-AMFC based on intelligent Proportional-Integral (
-iPI) control and the second is based on intelligent Proportional-Integral control combined with Sliding Mode Control (
-iPISMC). To obtain the controller parameters of the two
-AMFC structures, the particle swarm optimization (PSO) method was employed. The comparison of alternative approaches is performed by means of simulations including different scenarios. It is found that the
-iPISMC has a superior performance: it allows the output convergence 50 minutes earlier than the
-iPI and it is more robust against any sudden disturbances.