Job insecurity is a pervasive and impactful global concern, eliciting stress and affecting the health and well-being of employees worldwide. The present study (N = 679) examined the relationship between job insecurity and health and well-being and the moderating role of economic dependence and job satisfaction. When workers depended on their job as a source of income or when they were highly satisfied with their work, the relationship between job insecurity and health and well-being was exacerbated. The findings shed light on the complexities of individual variability in the relationship between job insecurity and health and well-being.