It may be possible to diagnose and monitor scarring, inflammation and edema in transplant kidney using reconstructive ultrasound elasticity imaging. Kidney elasticity is expected to change dramatically with scar, and to a lesser degree, with acute inflammation and edema. The hypothesis that changes in kidney elasticity can be imaged using a clinical ultrasound scanner was experimentally tested with an ex vivo canine kidney model, and results on a single pair of kidneys are reported in this paper. A cross-linking agent affected kidney elasticity both globally and locally. Elasticity changes were monitored with accurate estimates of internal displacement and strain followed by Young's modulus reconstruction. The results of this study strongly suggest that ultrasound elasticity imaging can detect elasticity changes in complex structures such as the kidney. Moreover, it has the potential to become an important clinical tool for renal transplant diagnosis.
U.S. Renal Data System, USRDS 1996 Annual Data Report (National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, April 1996).
HunsickerL.G.BennettL.E., Design of trials of methods to reduce late renal allograft loss: the price of success, Kidney Int.52, S120–3 (1995).
4.
EmelianovS.Y.LubinskiM.A.WeitzelW.F.WigginsR.C.SkovorodaA.R.O'DonnellM., Elasticity imaging for early detection of renal pathologies, Ultrasound Med. Biol.21, 871–883 (1995).
5.
RossE.A.WilkinsonA.HawkinsR.A.DanovtchG.M., The plasma creatinine concentration is not an accurate reflection of the glomerular filtration rate in stable renal transplant patients receiving cyclosporine, Am. J. Kidney Dis10, 113–7 (1987).
6.
LeveyA.S., Measurement of renal function in chronic renal disease, Kidney Int.38, 167–84 (1990).
7.
AderJ.L.TackI.DurandD.Tran-VanT.RostaingL.SucJ.M., Renal functional reserve in kidney and heart transplant recipients, J. Am. Soc. Nephrol.7, 1145–52 (1996).
8.
WilsonL.S.RobinsonD.E., Ultrasonic measurement of small displacements and deformations of tissues, Ultrasonic Imaging4, 71–82, 1982.
9.
KrouskopT.A.DoughertyD.R.LevinsonS.F., A pulsed Doppler ultrasonic system for making non-invasive measurements of the mechanical properties of soft tissue, J. Rehabil. Res. Dev.24, 1–8 (1987).
10.
BertrandM.MeunierJ.DoucetM.FerlandG., Ultrasonic Biomechanical strain gauge based on speckle tracking, in Proc. 1989 IEEE Ultrasonics Symp., pp. 859–864 (1989).
11.
LernerR.M.ParkerK.J.HolenJ.GramiakR.WaagR.C., Sono-elasticity: Medical elasticity images derived from ultrasound signals in mechanically vibrated targets, in Acoustical imaging, vol. 16, pp. 317–327 (Plenum Press, New York, 1988).
12.
YamakoshiY.SatoJ.SatoT., Ultrasonic imaging of internal vibration of soft tissue under forced vibration, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.17, 45–53 (1990).
13.
LernerR.M.HuangS.R.ParkerK.J., “Sonoelasticity” images derived from ultrasound signals in mechanically vibrated tissue, Ultrasound Med. Biol.16, 231–239 (1990).
14.
OphirJ.CespedesI.PonnekantiH.YazdiY.LiX., Elastography: A quantitative method for imaging the elasticity of biological tissues, Ultrasonic Imaging13, 111–134 (1991).
15.
GaoL.ParkerK.J.LernerR.M.LevinsonS.F., Imaging of the elastic properties of tissue - a review, Ultrasound Med. Biol.22, 959–977 (1996).
16.
OphirJ.CespedesI.GarraB.PonnekantiH.HuangY.MakladN., Elastography: ultrasonic imaging of tissue strain and elastic modulus in vivo, Euro J. Ultrasound3, 49–70 (1996).
17.
O'DonnellM.EmelianovS.Y.SkovorodaA.R.LubinskiM.A.WeitzelW.F.WigginsR.C., Quantitative Elasticity Imaging, in 1993 IEEE Ultrasonic Symp. Proc.2, pp. 893–903 (1993).
18.
O'DonnellM.SkovorodaA.R.ShapoB.M.EmelianovS.Y., Internal displacement and strain imaging using ultrasonic speckle tracking, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.41, 314–325 (1994).
19.
SkovorodaA.R.EmelianovS.Y.LubinskiM.A.SarvazyanA.P.O'DonnellM., Theoretical analysis and verification of ultrasound displacement and strain imaging, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.41, 302–313 (1994).
20.
TalhamiH.E.WilsonL.S.NealeM.L., Spectral tissue strain: a new technique for imaging tissue strain using intravascular ultrasound, Ultrasound Med. Biol.20, 759–772 (1994).
21.
AlamS.K.RichardsD.W.ParkerK.J., Detection of itraocular pressure change in the eye using sonoelstic Doppler ultrasound, Ultrasound Med. Biol.20, 751–758 (1994).
22.
SkovorodaA.R.EmelianovS.Y.O'DonnellM., Reconstruction of tissue elasticity based on ultrasound displacement and strain images, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.42, 747–765 (1995).
23.
EmelianovS.Y.SkovorodaA.R.LubinskiM.A.O'DonnellM., Reconstructive elasticity imaging, in Acoustical imaging, vol. 21, pp. 241–252 (Plenum press, New York, 1995).
24.
CespedesE.I.InsanaM.F.OphirJ., Theoretical bounds on strain estimation in Elastography, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.42, 969–972 (1995).
25.
BilgenM.InsanaM., Deformation models and correlation analysis in elastography, J. Acoust. Soc. Am.99, 3212–3224 (1996).
26.
DeKorteC.L.CespedesE.I.van der SteenA.F.W.NorderB.te NijenhuisK., Elastic and acoustic properties of vessel mimicking material for elasticity imaging, Ultrasonic Imaging19, 12–26 (1997).
27.
CohnN.A.EmelianovS.Y.LubinskiM.A.O'DonnellM., An elasticity microscope. Part I: methods, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.44, 1304–1319 (1997).
28.
CohnN.A.EmelianovS.Y.O'DonnellM., An elasticity microscope. Part II: experimental results, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.44, 1320–1331 (1997).
29.
FowlkesJ.B.EmelianovS.Y.PipeJ.G.SkovorodaA.R.AdlerR.S.CarsonP.L.SarvazyanA.P., Magnetic resonance imaging for detection of elasticity variation, Med. Phys.22, 1771–1778 (1995).
30.
MuthupillaiR.LomasD.J.RossmanP.J.GreenleafJ.F.ManducaA.EhmanR.L., Magnetic resonance elastography by direct visualization of propagating acoustic strain waves, Science269, 1854–1857 (1995).
31.
PlewesD.B.BettyI.UrchukS.N.SoutarI., Visualizing tissue compliance with MR imaging, J. Magnet. Reson. Imag.5, 733–738 (1995).
32.
ChenevertT.L.EmelianovS.Y.SkovorodaA.R., Elasticity reconstructive imaging using static displacement and strain estimations, in 1997Proc. International Soc. Magnetic Resonance in Medicine, p. 461.
SkovorodaA.R.LubinskiM.A.EmelianovS.Y.O'DonnellM., Nonlinear estimation of the lateral displacement using tissue incompressibility, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.45, 491–503 (1998).
37.
SkovorodaA.R.LubinskiM.A.EmelianovS.Y.O'DonnellM., Reconstructive elasticity imaging for large deformations, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.46, 523–535 (1999).
38.
LubinskiM.A.EmelianovS.Y.O'DonnellM., Speckle tracking methods for ultrasonic elasticity imaging using short time correlation, IEEE Trans. Ultrason. Ferroelect. Freq. Contr.46, 82–96 (1998).
DunnillM.S., Histopathology of rejection in renal transplantation, in Kidney Transplantation Principles and Practice, MorrisP.J., ed., pp. 439–472 (WB Saunders Company, Philadelphia, PA, 1988).
42.
EmelianovS.Y.LubinskiM.A.SkovorodaA.R.ErkampR.Q.LeaveyS.F.WigginsR.C.O'DonnellM., Reconstructive ultrasound elasticity imaging for renal pathology detection, in 1997IEEE Ultrasonic Symp. Proc.2, 1123–1126 (1998).
43.
ShapoB.M.CroweJ.R.ErkampR.Q.EmelianovS.Y.EberleM.J.O'DonnellM., Strain imaging of coronary arteries with intraluminal ultrasound: Experiments on an inhomogeneous phantom, Ultrasonic Imaging18, 173–191 (1996).
44.
ErkampR.Q.WigginsP.A.SkovorodaA.R.EmelianovS.Y.O'DonnellM., Measuring the elastic modulus of small tissue samples, Ultrasonic Imaging20, 17–28 (1997).
45.
ErkampR.WigginsP.SkovorodaR.EmelianovS.O'DonnellM., Gold standard system for reconstructive elasticity imaging, Ultrasonic Imaging19, 60–61 (1997) (abstract).
46.
EmelianovS.Y.ErkampR.Q.LubinskiM.A.SkovorodaR.O'DonnellM., Non-linear tissue elasticity: adaptive elasticity imaging for large deformations, in 1998 IEEE Ultrasonics Symp. Proc., pp. 1753–1756 (1998).
47.
KallelF.BertrandM., Tissue elasticity reconstruction using linear perturbation method, IEEE Trans. Med. Imag.15, 299–313 (1996).
48.
SumiC.NakayamaK., Elasticity tomography: Reconstruction using stable implicit-integration method, in 1996 IEEE Ultrasonics Symp. Proc., pp. 1325–1329 (IEEE catalog no.1051-0117-96, 1996).
