Sage Journals: Discover world-class research

Abstract

Objective

To evaluate the safety, tolerability, and voice outcomes of office-based photoangiolytic laser treatment of Reinke’s edema.

Study Design

Case series with chart review.

Setting

Academic medical center.

Subjects and Methods

We performed a retrospective analysis of patients undergoing office-based laser treatment of endoscopy-proven Reinke’s edema. Safety and tolerability were evaluated by reviewing complications. Voice outcomes were analyzed by comparing pre- and postprocedural acoustic, aerodynamic, and Voice Handicap Index measurements. Complete data sets were not available for all subjects; sample size for each parameter is reported with the corresponding result.

Results

Nineteen patients met inclusion criteria. There were no minor or major complications. Five procedures were truncated due to patient intolerance. Phonatory frequency range increased (n = 12, P = .003), while percent jitter decreased (n = 12, P = .004). Phonation threshold pressure decreased after treatment (n = 4, P = .049). Voice Handicap Index also decreased (n = 14, P < .001).

Conclusion

This study represents the largest series of patients undergoing office-based photoangiolytic laser treatment specifically for Reinke’s edema. Our data suggest that this is a safe and effective modality to treat dysphonia associated with Reinke’s edema, although patient intolerance of the procedure may represent a barrier.

Keywords

Reinke’s edema photoangiolytic laser office-based treatment voice

Get full access to this article

View all access options for this article.

References

Dursun

Ozgursoy

Kemal

Coruh

. One-year follow-up results of combined use of CO₂ laser and cold instrumentation for Reinke’s edema surgery in professional voice users. Eur Arch Otorhinolaryngol. 2007;264:1027-1032.

Marcotullio

Magliulo

Pezone

. Reinke’s edema and risk factors: clinical and histopathologic aspects. Am J Otolaryngol. 2002;23:81-84.

Chung

Tae

Lee

. The significance of laryngopharyngeal reflux in benign vocal mucosal lesions. Otolaryngol Head Neck Surg. 2009;141:369-373.

Cipriani

Martin

Corey

. The clinicopathologic spectrum of benign mass lesions of the vocal fold due to vocal abuse. Int J Surg Path. 2011;19:583-587.

Kamargiannis

Gouveris

Katsinelos

. Chronic pharyngitis is associated with severe acidic laryngopharyngeal reflux in patients with Reinke’s edema. Ann Otol Rhinol Laryngol. 2011;120:722-726.

Hojslet

Moesgaard-Nielsen

Karlsmore

. Smoking cessation in chronic Reinke’s oedema. J Laryngol Otol. 1990;104:626-628.

Hirano

Shin

Morio

. An improvement in surgical treatment for polypoid vocal cord: sucking technique. Otologia (Fukuoka). 1976;22:583-589.

Tan

NCW

Pittore

Puxeddu

. The “M” shaped microflap for treatment of complex Reinke’s space oedema of the vocal cords. Acta Otorhinolaryngologica Italica. 2010;30:259-263.

Sant’Anna

Mauri

. Use of the microdebrider for Reinke’s edema surgery. Laryngoscope. 2000;110:2114-2116.

10.

Yates

Dedo

. Carbon dioxide laser enucleation of polypoid vocal cords. Laryngoscope. 1984;94:731-736.

11.

Remacle

Lawson

Watelet

. Carbon dioxide laser microsurgery of benign vocal fold lesions: indications, techniques, and results in 251 patients. Ann Otol Rhinol Laryngol. 1999;108:156-164.

12.

Lumpkin

Bishop

Bennett

. Comparison of surgical techniques in the treatment of laryngeal polypoid corditis. Ann Otol Rhinol Laryngol. 1987;96:254-257.

13.

Pitmann

Lebowitz-Cooper

Iacob

Tan

. Effect of the 532nm pulsed KTP laser in the treatment of Reinke’s edema. Laryngoscope. 2012;122:2786-2792.

14.

Sheu

Sridharan

Kuhn

. Multi-institutional experience with the in-office potassium titanyl phosphate laser for laryngeal lesions. J Voice. 2012;26:806-810.

15.

Koufman

Rees

Frazier

. Office-based laryngeal laser surgery: a review of 443 cases using three wavelengths. Otolaryngol Head Neck Surg. 2007;137:146-151.

16.

Rees

Halum

Wijewickrama

Koufman

Postma

. Patient tolerance of in-office pulsed dye laser treatments to the upper aerodigestive tract. Otolaryngol Head Neck Surg. 2006;134:1023-1027.

17.

Zeitels

Burns

. Office-based laryngeal laser surgery with the 532-nm pulsed-potassium-titanyl-phosphate laser. Curr Opin Otolaryngol Head Neck Surg. 2007;15:394-400.

18.

Rees

Postma

Koufman

. Cost savings of unsedated office-based laser surgery for laryngeal papillomas. Ann Otol Rhinol Laryngol. 2007;116:45-48.

19.

Klussmann

Knoedgen

Wittekindt

Damm

Eckel

. Complications of suspension laryngoscopy. Ann Otol Rhinol Laryngol. 2002;111:972-976.

20.

Wuyts

de Bodt

Molenberghs

. The dysphonia severity index: an objective measure of vocal quality based on a multiparameter approach. J Speech Lang Hear Res. 2000;43:796-809.

21.

Jacobson

Johnson

Grywalski

. The Voice Handicap Index (VHI): development and validation. Amer J Speech Lang Pathol. 1997;6:66-70.

22.

Yan

Olszewski

Hoffman

. Use of lasers in laryngeal surgery. J Voice. 2010;24:102-109.

23.

Martins

Dominques

Fabro

Dias

Santana

. Reinkes’ edema: immunoexpression study of fibronectin, laminin and collagen IV in 60 cases by immunohistochemical techniques. Braz J Otorhinolaryngol. 2009;75:821-825.

24.

Mallur

Tajudeen

Aaronson

Branski

Amin

. Quantification of benign lesion regression as a function of 532-nm pulsed potassium titanyl phosphate laser parameter selection. Laryngoscope. 2011;121:590-595.

25.

Branski

Barbieri

Weksler

. Effects of transforming growth factor-beta1 on human vocal fold fibroblasts. Ann Otol Rhinol Laryngol. 2009;118:218-226.

26.

Lin

Yamashita

Zhang

Ling

Welham

. Pulsed dye laser-induced inflammatory response and extracellular matrix turnover in rat vocal folds and vocal fold fibroblasts. Lasers Surg Med. 2009;41:585-594.

27.

Mallur

Branski

Amin

. 532-nanometer potassium titanyl phosphate (KTP) laser-induced expression of selective matrix metalloproteinases (MMP) in the rat larynx. Laryngoscope. 2011;121:320-324.

28.

Young

Mallur

Wong

. Analysis of potassium titanyl phosphate laser settings and voice outcomes in the treatment of Reinke’s edema. Ann Otol Rhinol Laryngol. 2015;124:216-220.

29.

Mallur

Johns

3rd Amin

Rosen

. Proposed classification system for reporting 532-nm pulsed potassium titanyl phosphate laser treatment effects on vocal fold lesions. Laryngoscope. 2014;124:1170-1175.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

Office-Based Photoangiolytic Laser Treatment of Reinke’s Edema

Abstract

Objective

Study Design

Setting

Subjects and Methods

Results

Conclusion

Keywords

Get full access to this article

References

Supplementary Material