Over a period of two years the Scandinavian Society for Cell Toxicology* has met three times (on 21 October 1983 and 6–7 June 1984 in Uppsala, Sweden, and on 6–7 September 1985 in Roskilde, Denmark), to present research advances in cell toxicology and to discuss the effects of xenobiotics in isolated and cultured cells. The first part of this report represents a summary of these discussions. In the second part, some of the individual research reports presented by the participating members are summarised. The purpose is to give a review of problems currently dealt with in Scandinavian laboratories associated with the Society for Cell Toxicology.
ZbindenG., & Flury-RoversiM. (1981). Significance of the LD50 test for the toxicological evaluation of chemical substances.Archives of Toxicology47, 77–99.
2.
LindgrenP., ThelestamM., and LindquistN.G. (1983). First CFN Symposium: LD50 and possible alternatives.Acta Pharmacologica et Toxicologica52, Supplement II, 302.
3.
MalmforsT., and TeilingA. (1983). LD50—its value for the pharmaceutical industry in safety evaluation of drugs.Acta Pharmacologica et Toxicologica52, Supplement II, 229–246.
4.
EkwallB. (1983). Screening of toxic compounds in mammalian cell cultures.Annals of the New York Academy of Sciences407, 64–77.
5.
PetterssonB., CurvallM., and EnzellC.R. (1982). Effects of tobacco smoke compounds on the noradrenaline-induced oxidative metabolism in isolated brown fat cells.Toxicology18, 1–15.
6.
BernsonV. (1983). A comparison of the cellular toxicity of exhausts from cars driven on present and future fuels.Toxicology Letters19, 119–126.
7.
EkwallB. (1983). Correlation between cytotoxicity in vitro and LD50 values.Acta Pharmacologica et Toxicologica52, Supplement II, 80–99.
8.
WalumE., and PetersonA. (1984). On the application of cultured neuroblastoma cells in chemical toxicity screening.Journal of Toxicology and Environmental Health13, 511–520.
9.
DybingE., HolmeJ.A., GordonW.P., SoderlundE.J., DahlinD.C., and NelsonS.D. (1986). Genotoxicity studies with paracetamol.Mutation Research138, 21–32.
10.
HolmeJ.A., and SoderlundE.J. (1984). Modulation of genotoxic and cytotoxic effects of aromatic amines in monolayers of rat hepatocytes.Cell Biology and Toxicology1, 58–68.
11.
FarberE. (1984). Chemical carcinogenesis: a current biological perspective.Carcinogenesis5, 1–5.
12.
DanielW.F., and FishD.C. (1974). Environmental factors for the growth of animal cells.In Vitro120, 284–289.
13.
WerrleinR.J., and GlinosA.D. (1974). Oxygen microenvironment and respiratory oscillations in cultured mammalian cells.Nature251, 317–319.
14.
PetersonA., and WalumE. (1986). Use of a perfusion technique for measurements of respiratory activity in cultured cells.In Vitro, in press.
15.
PetersonA., LewneM., and WalumE. (1981). Acute toxicity of organic solvents, heavy metals and DDT tested in cultures of mouse neuroblastoma cells.Toxicology Letters9, 101–106.
16.
GrishamJ.W., and SmithG.J. (1984). Predictive and mechanistic evaluation of toxic responses in mammalian cell culture systems.Pharmacological Reviews36, 1515–1715.
17.
DawsonM. (1972). Cellular Pharmacology, 317 pp. Springfield, USA: Thomas.
18.
EkwallB., and JohanssonA. (1980). Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells.Toxicology Letters5, 299–307.
19.
BorenfreundB., and BorreroO. (1984). In vitro cytotoxicity assays: potential alternatives to the Draize ocular irritancy test.Cell Biology and Toxicology1, 55–65.
20.
EkwallB. (1980). Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells III: lethal action to man of 43 drugs related to HeLa cell toxicity of the lethal drug concentrations.Toxicology Letters5, 319–331.
21.
EkwallB. (1981). Preliminary studies on the validity of in vitro measurement of drug toxicity using HeLa cells IV: therapeutic effects and side effects of 50 drugs related to the HeLa toxicity of the therapeutic concentrations.Toxicology Letters7, 359–366.
22.
EkwallB. (1983). Good correlation between the cytotoxicity of drugs and their allergic side effects.In Vitro19, 222.
23.
BallsM., and HornerS.A. (1985). The FRAME interlaboratory programme on in vitro cytotoxicology.Food and Chemical Toxicology23, 209–213.
24.
JepsenA., ArenholtD., FiskerA.V., and PhilipsenH.P. (1983). Two-stage carcinogenesis in vitro.European Journal of Cancer and Clinical Oncology19, 1292.
25.
FiskesjöG. (1985). The Allium test as a standard in environmental monitoring.Heriditas102, 99–112.
26.
GrundtI.K., and NeskovicN.M. (1985). UDP galactose: ceramide galactosyl transferase and 2’,3’-cyclic-nucelotide 3’-phosphodiesterase activities in rat brain after long-term exposure to methylmercury or trimethyllead.Experimental Neurology88, 580–589.
27.
HarrapK.R., RichesP.G., GilbyE.D., SellwoodS.M., WilkinsonR., and KonyvesI. (1977). Studies on the toxicity and antitumour activity of prednimustine, a prednisolone ester of chlorambucil.European Journal of Cancer13, 873–881.
28.
LøberJ., MouridsenH.T., ChristiansenI.E., DoimbernowskyP., MattssonW., & RøthM. (1983). A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer.Cancer52, 1570–1576.
29.
DiplockA.T. (1976). Metabolic aspects of selenium action and toxicity.CRC Critical Reviews in Toxicology4, 271–328.
30.
GantherH.E. (1979). Metabolism of hydrogen selenide and methylated selenides.Advances in Nutrition Research2, 107–128.
31.
StåhlA, AnundiI., & HögbergJ. (1984). Selenite biotransformation to volatile metabolites in an isolated hepatocyte model system.Biochemical Pharmacology33, 1111–1117.
32.
AnundiI., StåhlA., & HögbergJ. (1984). Effects of selenite on O2 consumption GSH oxidation and NADPH levels in isolated hepatocytes and the role of redox changes in selenite toxicity.Chemical Biological Interactions50, 277–288.
33.
Hog¨bergJ., AnundiI., & StählA. (1984). The influence of oxygen on selenite metabolism. Abstract.International Congress on Pharmacology, London, 1925.
34.
AnundiI., HögbergJ., & StählA. (1982). Involvement of GSSG reductase in selenite metabolism and toxicity, studied in isolated hepatocytes.Archives of Toxicology50, 113–123.
35.
LähdetieJ., KaukopuroS., & PalvinenM. (1983). Genetic effects of ethyl methanesulfonate and X-rays at different stages of rat spermatogenesis studied by inhibition of DNA synthesis and induction of DNA repair in vitro.Hereditas99, 269–278.
36.
PetersonA., and WalumE. (1983). Growth and morphology of neuronal cell lines cultured in perfusion.In Vitro19, 875–880.
37.
RommertL., BernsonV., and PetterssonB. (1983). Effects of air pollutants on the oxidative metabolism and phagocytic capacity of pulmonary alveolar macrophages.Journal of Toxicology and Environmental Health12, 417–427.
38.
RommertL., and JenssenD. (1983). Rabbit alveolar macrophage-mediated mutagenesis of polycyclic hydrocarbons in V79 Chinese hamster cells.Mutation Research111, 245–252.
39.
HansonE. (1984). Cellular composition of a cerebral hemisphere primary culture.Neurochemical Research9, 153–172.
40.
SannerT., and RivedalE. (1986). Testing of 10 compounds in the Syrian hamster embryo cell transformation assay. In Collaborative Study of Short-term Tests for Carcinogens (ed. AshbyJ., de SerresF.J., DraperM., IshidateB., MargolinB., MatterB., ShelbyB.D.), New York: Elsevier/North Holland, in press.
41.
ThorenS., HolmaB., MontiM., & WadsöI. (1984). Micro-calorimetric measurements of heat production in rabbit alveolar macrophages.Thermochimica Acta72, 117–122.
42.
EricssonA.-Ch., & WalumE. (1984). Cytotoxicity of cyclophosphamide and acrylamide in glioma and neuroblastoma cell lines co-cultured with liver cells.Toxicology Letters20, 251–256.
43.
WalumE., VarnboI., and PetersonA. (1986). A multiple cell culture toxicity test system based on neuroblastoma C1300 cells and differentiated primary cultures of brain, muscle, heart and liver cells.Food and Chemical Toxicology, in press.
44.
WennbergA., HasselgrenG., and TronstadL. (1979). A method for toxicity screening of biomaterials using cells cultured on Millipore filters.Journal of Biomedical Materials Research13, 109–120.
