Previous studies have shown peripheral abnormalities in noradrenergic activity in depressed melancholic patients. These abnormalities have a relationship with short-term and long-term outcome. Little is known about the effects of antidepressant treatment on these peripheral measures such as plasma noradrenaline (NA) and the plasma NA response to a laboratory stressor, the cold pressor test (CPT). The present study examines the effects of the antidepressant reboxetine, a noradrenaline reuptake inhibitor, on baseline plasma NA and the plasma NA response to a CPT, in nine healthy volunteers compared to placebo. A double-blind crossover design was used, with each agent given for 4 weeks with a 4-week washout period. There was no effect of reboxetine on baseline plasma NA. The plasma NA response to reboxetine, with a CPT, was blunted 3 days after commencing treatment. Reboxetine alters the plasma NA response to a CPT independent of baseline plasma NA.
Benarroch E E (1992) Central neurotransmitters and neuromodulators in cardiovascular regulation. In Bannister R, Mathias C J (eds), Autonomic failure, a textbook of clinical disorders of the autonomic nervous system, 3rd edn, pp. 36–53. Oxford University Press, Oxford
2.
Bunney W E, Davis J M (1965) Norepinephrine in depressive reactions.Arch Gen Psychiatry13: 483–493
3.
Checkley S A, Glass I B, Thompson C, Corn T, Robinson P (1984) The GH response to clonidine in endogenous as compared with reactive depression.Psychol Med14: 773–777
4.
Cooper S J, Kelly J G, King D J (1985) Adrenergic receptors in depression.Br J Psychiatry147: 23–29
5.
Cooper S J, Kelly C B (2000) Plasma noradrenaline response to a cognitive stressor in subtypes of depressive illness.Hum Psychopharmacol Clin Exp15: 265–274
6.
Corona G L, Cucchi M L, Frattini G, Santagostino G, Schinelli P, Tosca P, et al. (1987) Amitriptyline action on sympathetic neuronal function in depressed women.Clin Exp Pharmacol Physiol14: 877–885
7.
Dostert P, Benedetti M S, Poggessi I (1997) Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor.Eur Neuropsychopharmacol7 (Suppl. 1): S23–S35
8.
Esler M, Turbott J, Schqarz R, et al.(1982) The peripheral kinetics of norepinephrine in depressive illness.Arch Gen Psychiatry39: 295–300
9.
Esler M D, Lambert G W, Ferrer C, Kaye D M, Wallin B G, Kalff F, et al. (1995) Central nervous system noradrenergic control of sympathetic outflow in normotensive and hypertensive humans.Clin Exp Hypertens17: 409–423
10.
Fava G A, Munari F, Pavan L, Kellner R (1981) Life events and depression. A replication. J Affect Disord3: 159–165
11.
Johnston T G, Kelly C B, Stevenson M R, et al. (1999) Plasma norepinephrine and prediction of outcome in major depressive disorder.Biol Psychiatry46: 1253–1258
12.
Kelly C B, Cooper S J (1997) Plasma noradrenaline response to electroconvulsive therapy in depressive illness.Br J Psychiatry171: 182–186
13.
Kelly C B, Cooper S J (1998a) Differences and variability in plasma noradrenaline between depressive and anxiety disorders.J Psychopharmacol12: 161–167
14.
Kelly C B, Cooper S J (1998b) Plasma norepinephrine response to a cold pressor test in subtypes of depressive illness.Psychiat Res81: 39–50
15.
Krstulovic A M, Dziedzic S W, Bertoni-Dziedzic L, Dirico D E (1981) Plasma catecholamines in hypertension and phaeochromocytoma determined using ion pair reverse phase chromatography with amperometric detection. Investigation of separation mechanism and clinical methodology. J Chromatogr217: 523–537
16.
Lambert G, Johansson M, Agren H, Friberg P (2000) Reduced brain norepinephrine and dopamine release in treatment refractory depressive illness: evidence in support of the catecholamine hypothesis of mood disorders.Arch Gen Psychiatry57: 787–793
17.
Linnoila M, Karoum F, Calil H, Kopin I J, Potter W Z (1982) Alterations of norepinephrine metabolism with desimipramine and zimeldidine in depressed patients.Arch Gen Psychiatry39: 1025–1028
18.
Maes M, Vandevoude M, Schatte C, Blockx P (1990) Positive relationship between the catecholaminergic turnover and the DST results in depression.Psychol Med20: 493–499
19.
Ross R J, Scheinin M, Lesieur P, et al. (1985) The effect of clorgyline on noradrenergic function.Psychopharmacology85: 227–230.
20.
Roy A, Pickar D, De Jong J, Karoum F, Linnoila M (1988) Norepinephrine and its metabolites in cerebrospinal fluid, plasma and urine. Relationship to hypothalamic–pituitary– adrenal axis function in depression. Arch Gen Psychiatry45:849–857
21.
Siever L J, Davis K L (1985) Overview: toward a dysregulation hypothesis of depression.Am J Psychiatry142: 1017–1029
22.
Veith R C, Raskind M A, Barnes R F, Gumbrecht G, Ritchie J L, Halter J B (1983) Tricyclic antidepressants and supine, standing and exercise plasma norepinephrine levels.Clin Pharmacol Ther33: 763–769
23.
Veith R C, Best J D, Halter J B (1984) Dose dependent suppression of norepinephrine appearance rate in plasma by clonidine in man.J Clin Endocrinol Metab59: 151–155
24.
Veith R C, Lewis N, Linares O A, Barners R F, Raskind M A, Villacrees E L, et al. (1994) Sympathetic nervous system activity in major depression.Arch Gen Psychiatry51: 411–422
25.
Waslick B D, Walsh T, Greenhill L L, Elsa-Grace V G, Sloan R P, Bigger J T et al. (1999) Cardiovascular effects of desipramine in children and adults during exercise testing.J Am Acad Child Adolesc Psychiatry38: 179–186
26.
Werstiuk E S, Coote M, Griffith L (1996) Effects of electroconvulsive therapy on peripheral adrenoceptors, plasma noradrenaline, MHPG and cortisol in depressed patients.Br J Psychiatry169: 758–765
27.
Ziegler M G, Lake C R, Wood J H, Brooks E R, Ebert M H (1977) Relationship between norepinephrine in blood and cerebrospinal fluid in the presence of a blood–cerebrospinal fluid barrier for norepinephrine.J Neurochem28: 677–679
