Restricted accessResearch articleFirst published online 1998-7
Production of Gastroesophageal Erosions and Ulcers (GEU) in Gnotobiotic Swine Monoinfected with Fermentative Commensal Bacteria and Fed High-carbohydrate Diet
Erosions and gastroesophageal ulcers (GEU) were produced in the pars esophagea of young gnotobiotic swine fed a carbohydrate-enriched liquid diet and monoinfected with two different fermentative commensal bacteria, Lactobacillus and Bacillus sp. In contrast, piglets, fed a similar diet and inoculated with Gastrospirillum sp. (Helicobacter heilmannii), a helicobacter species that colonizes the gastric mucosa, did not develop GEU. Experimental GEU likely develops secondary to epithelial damage mediated by microbial-origin acids whose production is potentiated by high dietary carbohydrate and parietal cell-origin hydrochloric acid.
ArgenzioRAEisemannJ:
Mechanisms of acid injury in pig gastroesophageal mucosa.
Am J Vet Res57:564–573, 1996
2.
ArgenzioRASouthworthM:
Sites of organic acid production and absorption in the gastrointestinal tract of the pig.
Am J Physiol228:454–462, 1975
3.
BarbosaAJASilvaJCPNogueiraAMMFPaulinoEJrMirandaCR:
Higher incidence of Gastrospirillum sp. in swine with gastric ulcer of the pars oesophagea.
Vet Pathol32:134–139, 1995
4.
BertramTAKrakowkaSMorganDR:
Gastritis associated with infection by Helicobacter pylori: comparative pathology in humans and swine.
Rev Infect Dis13:S714–S722, 1991
5.
ClausDBerkleyRCW:
Genus Bacillus. In:
Bergey's Manual of Systematic Bacteriology,
ed. SheathPHA, sect. 13,
pp. 1104–1139,
Williams & Wilkins, Baltimore, MD,
1995
6.
CorreaP:
Human gastric carcinogenesis: a multistep and multifactorial process.
Cancer Res52:6735–6740, 1992
7.
EatonKADewhirstFEPasterBJTzellasNColemanBEPaolaJSherdingR:
Prevalence and varieties of Helicobacter species in random-source and pet dogs; animal and public health implications.
J Clin Microbiol34:3165–3170, 1996
EatonKARadinMJKramerLWackRSherdingRKrakowkaSMorganDR:
Epizootic gastritis in cheetahs associated with gastric spiral bacilli.
Vet Pathol30:55–63, 1993
12.
EatonKARinglerSKrakowkaS:
Isolation of pure populations of Helicobacter heilmannii-like bacteria. In:
Campylobacters, Helicobacters and Related Organisms,
ed. NewellDGKetleyJMFeldmanRA,
pp. 25–31.
Plenum, New York, NY,
1996
EmbayeHThomlinsonJRLawrenceTLJ:
Histopathology of oesophagogastric lesions in pigs.
J Comp Pathol103:253–264, 1990
15.
HanninenMLHapponenISaariSJalavaK:
Culture and characteristics of Helicobacter bizzozeronii, a new canine gastric helicobacter ssp.
Int J Syst Bacteriol46:160–166, 1995
16.
HeilmannKLBorchardF:
Gastritis due to spiral shaped bacteria other than Helicobacter pylori: clinical, histological and ultrastructural findings.
Gut32:137–140, 1991
17.
HenrikssonAConwayPL:
Adhesion to porcine squamous epithelium of saccharide and protein moieties of Lactobacillus fermentum strain 104-S.
J Gen Microbiol138:2657–2661, 1992
18.
HenrikssonAConwayPL:
Adhesion of Lactobacillus fermentum 104-S to porcine stomach mucus.
Curr Microbiol33:31–34, 1996
19.
HenryGALongPHBurnsJLCharbonneauDL:
Gastric spirillosis in Beagles.
Am J Vet Res48:831–836, 1987
20.
HussellTIsaacsonPGCrabtreeJESpencerJ:
The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori.
Lancet342:571–574, 1993
21.
KandlerOWeissN:
Genus Lactobacillus. In:
Bergey's Manual of Systematic Bacteriology,
ed. KandlerOWeissN, sect. 14,
pp. 1209–1234.
Williams & Wilkins, Baltimore, MD,
1995
22.
KrakowkaSEatonKA:
Helicobacter pylori infection in gnotobiotic piglets: a model of human gastric bacterial disease. In:
Advances in Swine in Biomedical Research,
ed. TumblesonMSchookL,
vol. 2, pp. 779–810.
Plenum, New York, NY,
1996
23.
KrakowkaSEatonKARingsDM:
Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori.
Infect Immun63:2352–2355, 1995
24.
KrakowkaSMorganDRKraftWOLeunkR:
Establishment of gastric Campylobacter pylori infection in the neonatal piglet.
Infect Immun55:2789–2796, 1987
25.
KivilaaksoEFrommDSilenW:
Relationship between ulceration and intramural pH of gastric mucosa during hemorrhagic shock.
Surgery84:70–77, 1978
26.
LidbeckANordCE:
Lactobacilli and the normal human anaerobic microflora.
Clin Infect Dis4:181–187, 1993
27.
MossSCalamJ:
Helicobacter pylori and peptic ulcers: the present position.
Gut33:289–292, 1992
28.
National Institutes of Health:
Helicobacter pylori in peptic ulcer disease.
NIH Consens Statement12:1–17, 1994
29.
NomuraAStemmermannGNChyouPHKatoIPerez-PerezGFBlaserMJ:
Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii.
N Engl J Med325:1132–1136, 1991
30.
O'BrienJJ:
Gastric ulcers. In:
Diseases of Swine,
ed. LemanAD,
6th ed., pp. 680–691.
Iowa State University Press, Ames, IA,
1986
31.
ParsonnetJVandersteenDGoatesJSibleyRKPritikinJChangY:
Helicobacter pylori infection in intestinal and diffuse-type gastric adenocarcinomas.
J Natl Cancer Inst83:640–643, 1991
32.
PetersonWL:
Helicobacter pylori and peptic ulcer disease.
N Engl J Med324:1043–1047, 1991
33.
PrichardPJYeomansND:
Helicobacter pylori and duodenal ulcer.
J Gastroenterol Hepatol6:177–178, 1991
34.
QueirozDMMRochaGAMendesENLageAPCarvalhoACTBarbosaAJA:
A spiral microorganism in the stomach of pigs.
Vet Microbiol24:199–204, 1990
35.
ShermanLASavageDC:
Lipoteichoic acid in Lactobacillus strains that colonize mouse gastric epithelium.
Appl Environ Microbiol52:302–304, 1986
36.
SipponenP:
Helicobacter pylori and chronic gastritis: an increased risk of peptic ulcer. A review.
Scand J Gastroenterol26:6–10, 1991
37.
SipponenP:
Helicobacter pylori infection–a common worldwide environmental risk factor for gastric cancer?Endoscopy24:424–426, 1992
38.
SolnickJVO'RourkeJLeeAPasterBJDewhirstFETompkinsLS:
An uncultured gastric spiral organism is a newly identified Helicobacter in humans.
J Infect Dis168:379–385, 1993
