Amiodarone, a class III antiarrhythmic, has been widely used to treat both ventricular and supraventricular arrhythmias. Despite the multitude of side-effects seen with this drug, no case of amiodarone anaphylaxis (confirmed by mast cell tryptase levels and skin testing) has been reported in the medical literature. We report a case of anaphylaxis to intravenous amiodarone in a 77-year-old patient.
FisherM.Intradermal testing after anaphylactoid reaction to anaesthetic drugs: practical aspects of performance and interpretation. Anaesth Intensive care1984; 12: 115–120.
2.
RavishankarR., SamuelsL.E., KaufmanM.S.Amiodarone-associated hemoptysis. Am J Med Sci1998; 316: 390–392.
3.
SanguinettiM.C., JurkiewiczN.K.Block of a novel cardiac K+ current by calss III antiarrhythmic agents. Circulation1989; 80: S607.
4.
FollmerC., AomineM., YehJ., SingerD.H.Amiodarone-induced block of sodium current in isolated cardiac cells. J Pharmacol Exp Ther1987; 243: 187–194.
5.
NishimuraM., FollmerC.H., SingerD.H.Amiodarone blocks calcium current in single guinea pig ventricular myocytes. J Pharmacol Exp Ther1989; 251: 650–659.
6.
CokerS.J., Chess-WilliamsW.R.Amiodarone, adrenoceptor responsiveness and ischaemia and reperfusion-induced arrhythmias. Eur J Pharmacol1991; 201: 103–109.
7.
Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care.Part 6: ACLS. Circulation2000; 102: S112–165.
8.
MaiselW.H., RawnJ.D., StevensonW.G.Atrial fibrillation after cardiac surgery. Ann Intern Med2001; 135: 1061–1073.
9.
MillerJ.M., ZipesD.P.Management of the patient with cardiac arrhythmia. In: BraunwaldE., ZipesD.P., LibbyP. eds. Heart Disease: A Textbook of Cardiovascular Medicine, 6th Ed. W. B. Saunders2001; 700–774.
EdstonE., van Hage-HamstenM.Immunoglobulin E, mast cell-specific tryptase and the complement system in sudden death from coronary artery thrombosis. Int J Cardiol1995; 52: 77–81.
