Endocrine research in animals often entails exogenous hormone administration. Special issues arise when developing administration protocols for hormones with circadian and seasonal periodicity. This article reviews various methods for the exogenous administration of hormones with such periodicities by focusing on melatonin. We discuss that methodological variations across studies can affect experimental results. Melatonin administration techniques used in vertebrates includes infusion pumps, beeswax pellets, oral administration, injections, SILASTIC capsules, osmotic pumps, transdermal delivery, beads, and sponges.
AbeCTashiroTTanakaKOgiharaRMoritaH (2009) A novel type of implantable and programmable infusion pump for small laboratory animals. J Pharmacol Toxicol Methods59:7-12.
2.
AdanAArcherSNHidalgoMPDi MiliaLNataleVRandlerC (2012) Circadian typology: a comprehensive review. Chronobiol Int29:1153-1175
3.
AldhousMFraneyCWrightJArendtJ (1985) Plasma concentrations of melatonin in man following oral absorption of different preparations. Br J Clin Pharmacol19:517-521
4.
AlvariñoJRandallCBromageN (1993) Effects of skeleton photoperiods on melatonin secretion in the rainbow trout, Oncorhynchus mykiss (Walbaum). Aquacult Res24:157-162
5.
ArendtJAldhousMMarksV (1986) Alleviation of jet lag by melatonin: preliminary results of controlled double blind trial. Br Med J292:1170
6.
ArendtJSkeneDJMiddletonBLockleySWDeaconS (1997) Efficacy of melatonin treatment in jet lag, shift work, and blindness. J Biol Rhythms12:604-617
7.
ArendtJSymonsALaudCPrydeS (1983) Melatonin can induce early onset of the breeding season in ewes. J Endocrinol97:395-400
8.
AxelrodJ (1974) The pineal gland: a neurochemical transducer. Science184:1341-1348
9.
BalasubramanianKSaxenaR (1973) Effect of pinealectomy and photoperiodism in the reproduction of Indian weaver birds, Ploceus philippinus. J Exp Zool185:333-340
10.
BartnessTGoldmanB (1989) Mammalian pineal melatonin: a clock for all seasons. Experientia45:939-945
11.
BartnessTJWadeGN (1985) Body weight, food intake and energy regulation in exercising and melatonin-treated Siberian hamsters. Physiol Behav35:805-808
12.
BartnessTPowersJHastingsMBittmanEGoldmanB (1993) The timed infusion paradigm for melatonin delivery: what has it taught us about the melatonin signal, its reception, and the photoperiodic control of seasonal responses?J Pineal Res15:161-190
13.
BayarriMJde LamaMÁRMadridJASánchez-VázquezFJ (2003) Both pineal and lateral eyes are needed to sustain daily circulating melatonin rhythms in sea bass. Brain Res969:175-182
14.
BechgaardELindhardtKMartinsenL (1999) Intranasal absorption of melatonin in vivo bioavailability study. Int J Pharm182:1-5
15.
BedrosianTAHerringKLWaltonJCFonkenLKWeilZMNelsonRJ (2013) Evidence for feedback control of pineal melatonin secretion. Neurosci Lett542:123-125
16.
BenoîtJ (1935) Stimulation par la lumiere artificielle du developpement testiculaire chez des canards aveugles par section du nerf optique. C R Seances Soc Biol Filiales120, 133-136
17.
BentleyGEDemasGENelsonRJBallGF (1998) Melatonin, immunity and cost of reproductive state in male European starlings. Proc Royal Soc London B Biol Sci265:1191-1195
18.
BentleyGEVan’t HofTJBallGF (1999) Seasonal neuroplasticity in the songbird telencephalon: a role for melatonin. Proc Natl Acad Sci96:4674-4679
19.
BertholdAA (1849) Transplantation of testes, trans. DP Quiring. Bull History Med16:399-401
20.
BittmanEL (1993) The sites and consequences of melatonin binding in mammals. American Zoologist33:200-211
21.
BittmanELDempseyRJKarschFJ (1983) Pineal Melatonin Secretion Drives the Reproductive Response to Daylength in the Ewe. Endocrinol113:2276-2283
22.
BittmanELKarschFJ (1984) Nightly duration of pineal melatonin secretion determines the reproductive response to inhibitory day length in the ewe. Biol Reprod30:585-593
23.
BoulosZMacchiMTermanM (1996) Effects of twilights on circadian entrainment patterns and reentrainment rates in squirrel monkeys. J Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology179:687-694
24.
BoulosZTermanJTermanM (1996) Circadian phase-response curves for simulated dawn and dusk twilights in hamsters. Physiol Behav60:1269
25.
BrainardGCRichardsonBAHurlbutECSteinlechnerSMatthewsSAReiterRJ (1984) The influence of various irradiances of artificial light, twilight, and moonlight on the suppression of pineal melatonin content in the Syrian hamster. J Pineal Res1:105-119
26.
BrynildsenJKNajarJHsuL-MVaupelDBLuHRossTJYangYSteinEA (2016) A novel method to induce nicotine dependence by intermittent drug delivery using osmotic minipumps. Pharmacology Biochemistry and Behavior, 142, 79–84
27.
BubenikGA (2001) Localization, physiological significance and possible clinical implication of gastrointestinal melatonin. Neurosignals10:350-366
28.
BubenikGBrownG (1997) Pinealectomy reduces melatonin levels in the serum but not in the gastrointestinal tract of rats. Neurosignals6:40-44
29.
BubenikGSmithP (1987) Circadian and circannual rhythms of melatonin in plasma of male white-tailed deer and the effect of oral administration of melatonin. J Exp Zoology241:81-89
30.
BuffoniAVozziPGonzalezDRiosGViegas-BordeiraHAbeciaJ (2014) The effect of melatonin and season on in vivo embryo production of Dohne Merino ewes. Small Ruminant Res120:121-124
31.
BurkhardtSTanDXManchesterLCHardelandRReiterRJ (2001) Detection and quantification of the antioxidant melatonin in Montmorency and Balaton tart cherries (Prunus cerasus). J Agricultural Food Chem49:4898-4902
32.
CalisiRMBentleyGE (2009) Lab and field experiments: are they the same animal?Hormones and Behavior56:1-10
33.
CampaigneEDinnerA (1970) Benzo [b] thiophene derivatives. XVI. Sulfur isosteres of melatonin, bufotenine, 5-hydroxytryptophan, and related structures. J Medicinal Chemistry13:1205-1208
34.
CarterDSGoldmanBD (1983) Antigonadal effects of timed melatonin infusion in pinealectomized male Djungarian hamsters (Phodopus sungorus sungorus): duration is the critical parameter. Endocrinology113:1261-1267
35.
CassoneVMChesworthMJArmstrongSM (1986a) Dose-dependent entrainment of rat circadian rhythms by daily injection of melatonin. J Biol Rhythms1:219-229
36.
CassoneVMChesworthMJArmstrongSM (1986b) Entrainment of rat circadian rhythms by daily injection of melatonin depends upon the hypothalamic suprachiasmatic nuclei. Physiol Behav36:1111-1121
37.
ChampneyTHPradoJYoungbloodTAppelKMcMurrayDN (1997) Immune responsiveness of splenocytes after chronic daily melatonin administration in male Syrian hamsters. Immunol Lett58:95-100
38.
ChenHDiKQHaoEYYeMZhaQCLiLHBaiKHuangRL (2016) Effects of exogenous melatonin and photoperiod on sexual maturation in pullets. J Anim Physiol Anim Nutr100:46-52
39.
CheungPWMcCormackCE (1983) Splitting of the locomotor activity rhythm in rats by exposure to continuous light. Am J Physiol Reg Integr Comp Physiol244:R573-R576
40.
CogburnLAWilson-PlacentraSLetcherLR (1987) Influence of pinealectomy on plasma and extrapineal melatonin rhythms in young chickens (Gallus domesticus). Gen Comp Endocrinol68:343-356.
41.
DaanSAschoffJ (1975) Circadian rhythms of locomotor activity in captive birds and mammals: their variations with season and latitude. Oecologia18:269-316
42.
DaanSDamassaDPittendrighCSSmithER (1975) An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus). Proc Natl Acad Sci U S A72:3744-3747
43.
Dabbeni-SalaFDi SantoSFranceschiniDSkaperSDGiustiP (2001) Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity. FASEB J15:164-170
44.
DaltonEJRotondiDLevitanRDKennedySHBrownG (2000) Use of slow-release melatonin in treatment-resistant depression. J Psychiatry Neurosci25:48
45.
DashevskyAMohamadA (2006) Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat ECD. Int J Pharma318:124-131
46.
DawsonDRogersNLvan den HeuvelCJKennawayDJLushingtonK (1998) Effect of sustained nocturnal transbuccal melatonin administration on sleep and temperature in elderly insomniacs. J Biol Rhythms13:532-538
47.
de JongMJeningaLOuyangJQvan OersKSpoelstraKVisserME (2016) Dose-dependent responses of avian daily rhythms to artificial light at night. Physiol Behav155:172-179
48.
DelahuntyGBauerGPrackMde VlamingV (1978) Effects of pinealectomy and melatonin treatment on liver and plasma metabolites in the goldfish, Carassius auratus. Gen Comp Endocrinol35:99-109
49.
DickensMJDelehantyDJRomeroLM (2009) Stress and translocation: alterations in the stress physiology of translocated birds. Proc R Soc Lond Biol Sci276:2051–2056
50.
DickensMJEarleKARomeroLM (2009) Initial transference of wild birds to captivity alters stress physiology. Gen Comp Endocrinol160:76–83
51.
do RegoJLVaudryH (2016) Comparative aspects of neurosteroidogenesis: From fish to mammals. Gen Comp Endocrinol227:120-129
52.
DominoniDMGoymannWHelmBParteckeJ (2013) Urban-like night illumination reduces melatonin release in European blackbirds (Turdus merula): implications of city life for biological time-keeping of songbirds. Front Zool10:60.
53.
DubeyVMishraDAsthanaAJainNK (2006) Transdermal delivery of a pineal hormone: melatonin via elastic liposomes. Biomaterials27:3491-3496
DubocovichMLMarkowskaM (2005) Functional MT1 and MT2 melatonin receptors in mammals. Endocrine27:101-110
56.
EkmanALeppäluotoJHuttunenPArankoKVakkuriO (1993) Ethanol inhibits melatonin secretion in healthy volunteers in a dose-dependent randomized double blind cross-over study. J Clin Endocrinol Metabol77:780-783
57.
Fernández-MarMMateosRGarcía-ParrillaMPuertasBCantos-VillarE (2012) Bioactive compounds in wine: Resveratrol, hydroxytyrosol and melatonin: A review. Food Chem130:97-813
58.
FoàAJanikDMinutiniL (1992) Circadian rhythms of plasma melatonin in the ruin lizard Podarcis sicula: effects of pinealectomy. J Pineal Res12:109-113
59.
FoàAMenakerM (1988) Contribution of pineal and retinae to the circadian rhythms of circulating melatonin in pigeons. J Comp Physiol164:25-30
60.
FolkmanJLongDM (1964) The use of silicone rubber as a carrier for prolonged drug therapy. J Surg Res4:139-142
61.
FreemanDAZuckerI (2001) Refractoriness to melatonin occurs independently at multiple brain sites in Siberian hamsters. Proc Natl Acad Sci U S A98:6447-6452
62.
FreudenbergerDToyakawaKBarryTBallASuttieJ (1994) Seasonality in digestion and rumen metabolism in red deer (Cervus elaphus) fed on a forage diet. Br J Nutr71:489-499
63.
FusaniL (2008) Endocrinology in field studies: problems and solutions for the experimental design. Gen Comp Endocrinol157:249-253
64.
FusaniL.CardinaleM.SchwablI.GoymannW. (2011). Food availability but not melatonin affects nocturnal restlessness in a wild migrating passerine. Hormones and Behavior, 59(1), 187–192.
65.
FusaniLCocconFMoraARGoymannW (2013) Melatonin reduces migratory restlessness in Sylvia warblers during autumnal migration. Front Zool10:1
66.
GabelVMaireMReichertCFChellappaSLSchmidtCHommesVViolaAUCajochenC (2013) Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels. Chronobiol Int30:988-997
67.
Garcia-ParrillaMCCantosETroncosoAM (2009) Analysis of melatonin in foods. J Food Compost Anal22:177-183
68.
GerdinMJMasanaMIDubocovichML (2004) Melatonin-mediated regulation of human MT 1 melatonin receptors expressed in mammalian cells. Biochem Pharmacol67:2023-2030
69.
GerdinMJMasanaMIRivera-BermudezMAHudsonRLEarnestDJGilletteMUDubocovichML (2004) Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. FASEB J18:1646-1656
70.
GernWANorrisDO (1979) Plasma melatonin in the neotenic tiger salamander (Ambystoma tigrinum): effects of photoperiod and pinealectomy. Gen Comp Endocrinol38:393-398
71.
GibbsFP (1976) Correlation of plasma corticosterone levels with running activity in the blinded rat. Am J Physiol Legacy Content231:817-821
72.
GlassJKnottsL (1987) A Brain Site for the Antigonadal Action of Melatonin in the White-Footed Mouse (Peromyscus leucopus): Involvement of the Immunoreactive GnRH Neuronal System. Neuroendocrinology46:48-55
73.
GlassJ LynchG (1982) Evidence for a brain site of melatonin action in the white-footed mouse, Peromyscus leucopus. Neuroendocrinology34:1-6
74.
GormanMRZuckerI (1997) Pattern of change in melatonin duration determines testicular responses in Siberian hamsters, Phodopus sungorus. Biol Reprod56:668-673
75.
GotoMOshimaITomitaTEbiharaS (1989) Melatonin content of the pineal gland in different mouse strains. J Pineal Res7:195-204
76.
GoymannWSchwablITrappschuhMHauM (2007) Use of ethanol for preserving steroid and indoleamine hormones in bird plasma. Gen Comp Endocrinol150:191-195
77.
GoymannWTrappschuhMFusaniL (2008) A gentler method to raise melatonin levels in birds. J Biol Rhythms23:274-278
78.
GreivesTJKingmaSABeltramiGHauM (2012) Melatonin delays clutch initiation in a wild songbird. Biol Lett8:330-332
79.
GreivesTJKingmaSAKranstauberBMortegaKWikelskiMvan OersKMatemanCFergusonGABeltramiGHauM (2015) Costs of sleeping in: circadian rhythms influence cuckoldry risk in a songbird. Funct Ecol29:1300-1307
80.
GronfierCWrightKPKronauerREJewettMECzeislerCA (2004) Efficacy of a single sequence of intermittent bright light pulses for delaying circadian phase in humans. Am J Physiol Endocrinol Metab287:E174-E181
81.
GuoHBrewerJMChamphekarAHarrisRBBittmanEL (2005) Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals. Proc Natl Acad Sci U S A102:3111-3116
82.
Guyomarc’hCLumineauSVivien-RoelsBRichardJ-PDerégnaucourtS (2001) Effect of melatonin supplementation on the sexual development in European quail (Coturnix coturnix). Behav Process53:121-130
83.
GwinnerEGTurekFWSmithSD (1971) Extraocular light perception in photoperiodic responses of the white-crowned sparrow (Zonotrichia leucophrys) and of the golden-crowned sparrow (Z. atricapilla). Zeitschrift Für Vergleichende Physiologie75:323-331
84.
HastingsMHDuffieldGEEblingFJKiddAMaywoodESSchurovI (1997) Non-photic signaling in the suprachiasmatic nucleus. Biol Cell89:495-503
85.
HauMGwinnerE (1994) Melatonin facilitates synchronization of sparrow circadian rhythms to light. J Comp Physiol175:343-347
86.
HauMGwinnerE (1995) Continuous melatonin administration accelerates resynchronization following phase shifts of a light-dark cycle. Physiol Behav58:89-95
87.
HeiglSGwinnerE (1995) Synchronization of circadian rhythms of house sparrows by oral melatonin: effects of changing period. J Biol Rhythms10:225-233
88.
HerxheimerA.PetrieK. J. (2001). Melatonin for preventing and treating jet lag. The Cochrane database of systematic reviews, (1), CD001520.
89.
HommaKMcFarlandLZWilsonWO (1967) Response of the reproductive organs of the Japanese quail to pinealectomy and melatonin injections. Poultry Sci46:314-319
90.
HommaKWilsonWSiopesT (1972) Eyes have a role in photoperiodic control of sexual activity of Coturnix. Science178:421-423
91.
HonmaSKanematsuNKatsunoYHonmaK (1992) Light suppression of nocturnal pineal and plasma melatonin in rats depends on wavelength and time of day. Neurosci Lett147: 201-204
92.
HortonT (1984) Growth and maturation in Microtus montanus: effects of photoperiods before and after weaning. Can J Zool62:1741-1746
93.
HuetherG (1993) The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia49:665-670
94.
HydeLLUnderwoodH (1995) Daily melatonin infusions entrain the locomotor activity of pinealectomized lizards. Physiol Behav58:943-951
95.
JanikDDittamiJGwinnerE (1992) The effect of pinealectomy on circadian plasma melatonin levels in house sparrows and European starlings. J Biol Rhythms7:277-286.
96.
JohnsonDGBorkholderDA (2016) Towards an Implantable, Low Flow Micropump That Uses No Power in the Blocked-Flow State. Micromachines7:99.
97.
JohnsonMS (1926) Activity and distribution of certain wild mice in relation to biotic communities. J Mammal7:245-277
98.
JussTSMeddleSLServantRSKingVM (1993) Melatonin and photoperiodic time measurement in Japanese quail (Coturnix coturnix japonica). Proc R Soc Lond Biol Sci254:21-28
99.
KangSLeclercBKosonsirilukSMauroLIwasawaAEl HalawaniM (2010) Melanopsin expression in dopamine-melatonin neurons of the premammillary nucleus of the hypothalamus and seasonal reproduction in birds. Neuroscience170:200-213
100.
KangSThayananuphatABakkenTEl HalawaniM (2007) Dopamine-melatonin neurons in the avian hypothalamus controlling seasonal reproduction. Neuroscience150:223-233
101.
KaruppagounderSSShiQXuHGibsonGE (2007) Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Neurobiol Dis26:353-362
102.
KennawayDSeamarkR (1980) Circulating levels of melatonin following its oral administration or subcutaneous injection in sheep and goats. Aust J Biol Sci33:349-354
103.
KilicEHermannDMIsenmannSBährM (2002) Effects of pinealectomy and melatonin on the retrograde degeneration of retinal ganglion cells in a novel model of intraorbital optic nerve transection in mice. J Pineal Res32:106-111
KleinDCMooreRY (1979) Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Res174:245-262
KonturekSKonturekPBrzozowskiTBubenikG (2007) Role of melatonin in upper gastrointestinal tract. J Physiol Pharmacol58:23-25
108.
KoreshEMatasDKorenL (2016) Experimental elevation of wildlife testosterone using silastic tube implants. Res Vet Sci108:1-7
109.
KriegsfeldLJBittmanEL (2010) Photoperiodism and reproduction in mammals. In Photoperiodism: The Biological Calendar. NelsonRJDenlingerDSommersD eds, pp 503-542. New York: Oxford University Press
110.
KriegsfeldL. J.SilverR. (2006). The regulation of neuroendocrine function: timing is everything. Hormones and Behavior, 49(5), 557–574.
111.
KumarVFollettB (1993) The circadian nature of melatonin secretion in Japanese quail (Coturnix coturnix japonica). J Pineal Res14:192-200
112.
KumariYRaniSTsutsuiKKumarV (2015) Duration of melatonin regulates seasonal plasticity in subtropical Indian weaver bird, Ploceus philippinus. Gen Comp Endocrinol220:46-54
113.
LaneEAMossHB (1985) Pharmacokinetics of melatonin in man: first pass hepatic metabolism. J Clin Endocrinol Metab61:1214-1216
114.
Le TallecTPerretMThéryM (2013) Light pollution modifies the expression of daily rhythms and behavior patterns in a nocturnal primate. PloS One8:e79250
115.
LeeBMinGCuiJ (1999) Correlation of drug solubility with trapping efficiency and release characteristics of alginate beads. Pharm Pharmacol Commun5:85-89
116.
LeeB-JChoeJKimC-K (1998) Preparation and characterization of melatonin-loaded stearyl alcohol microspheres. J Microencap15:775-787
117.
LeeB-JMinG-H (1996) Oral controlled release of melatonin using polymer-reinforced and coated alginate beads. Int J Pharm144:37-46
118.
LeeB-JMinG-HKimT-W (1996) Preparation and in vitro release of melatonin-loaded multivalent cationic alginate beads. Arch Pharmacal Res19:280
119.
LeeB-JParrottKAAyresJWSackRL (1995). Design and evaluation of an oral controlled release delivery system for melatonin in human subjects. Int J Pharmaceutics124:119-127
120.
LeeB-JParrottKAAyresJWSackRL (1996) Development and characterization of an oral controlled-release delivery system for melatonin. Drug Develop Ind Pharm22:269-274
121.
LemleyCOCamachoLEVonnahmeKA (2013) Uterine infusion of melatonin or melatonin receptor antagonist alters ovine feto-placental hemodynamics during midgestation. Biol Reprod89:40.
122.
LewisPMiddletonBGousR (2006) Exogenous melatonin modifies rate of sexual maturation in domestic pullets. Poultry Sci85:117-122
123.
LewyAJAhmedSJacksonJMLSackRL (1992) Melatonin shifts human orcadian rhythms according to a phase-response curve. Chronobiol Int9:380-392
124.
LewyAJTetsuoMMarkeySGoodwinFKKopinI (1980) Pinealectomy abolishes plasma melatonin in the rat. J Clin Endocrinol Metab50:204-205
125.
LinAM-YHoL-T (2000) Melatonin suppresses iron-induced neurodegeneration in rat brain. Free Radical Biol Med28:904-911
126.
LuridianaSMuraMDagaCFarciFDi StefanoMZiddaFCarcangiuV (2015) Melatonin treatment in spring and reproductive recovery in sheep with different body condition score and age. Anim Reprod Sci160:68-73
127.
LynchHRivestRWurtmanC (1980) Artificial induction of melatonin rhythms by programmed microinfusion. Neuroendocrinology31:106-111
128.
MalpauxBRobinsonJBrownMKarschF (1988) Importance of changing photoperiod and melatonin secretory pattern in determining the length of the breeding season in the Suffolk ewe. J Reproduct Fertil83:461-470
129.
MaoSChenJWeiZLiuHBiD (2004) Intranasal administration of melatonin starch microspheres. Int J Pharm272:37-43
130.
MarumotoNMurakamiNKatayamaTKurodaHMurakamiT (1996) Effects of daily injections of melatonin on locomotor activity rhythms in rats maintained under constant bright or dim light. Physiol Behav60:767-773
131.
MarumotoNMurakamiNKurodaHMurakamiT (1996) Melatonin accelerates reentrainment of circadian locomotor activity rhythms to new light-dark cycles in the rat. Jpn J Physiol46:347-350
132.
MerrowMSpoelstraKRoennebergT (2005) The circadian cycle: daily rhythms from behaviour to genes. EMBO Rep6:930-935
133.
MorinL (1980) Effect of ovarian hormones on synchrony of hamster circadian rhythms. Physiol Behav24:741-749
134.
MotilvaVCabezaJLa LastraC (2001) New issues about melatonin and its effects on the digestive system. Curr Pharmaceutical Design7:909-931
135.
NelsonRJZuckerI (1981) Absence of extraocular photoreception in diurnal and nocturnal rodents exposed to direct sunlight. Comp Biochem Physiol A69:145-148
136.
NowakRRodwayR (1985) Effect of intravaginal implants of melatonin on the onset of ovarian activity in adult and prepubertal ewes. J Reprod Fertil74:287-293
137.
OhH-JOhY-KKimC-K (2001) Effects of vehicles and enhancers on transdermal delivery of melatonin. Int J Pharmaceutics212:63-71
138.
OliverJBayleJ (1982) Brain photoreceptors for the photo-induced testicular response in birds. Experientia38:1021-102
139.
PangSChowPWongTTsoE (1983) Diurnal variations of melatonin and N-acetylserotonin in the tissues of quails (Coturnix sp.), pigeons (Columba livia), and chickens (Gallus domesticus). Gen Comp Endocrino51:1-7
140.
PaulMJZuckerISchwartzWJ (2008) Tracking the seasons: the internal calendars of vertebrates. Philos Trans R Soc Lond B Biol Sci363:341-361
141.
PelhamR (1975) A serum melatonin rhythm in chickens and its abolition by pinealectomy. Endocrinology96:543-546
142.
PetterborgLJReiterRJ (1981) Effects of Photoperiod and Subcutaneous Melatonin Implants on the Reproductive Status of Adult White-footed Mice (Peromyscus leucopus). J Androl2:222-224
143.
PevetPAgezLBothorelBSaboureauMGauerFLaurentVMasson-PévetM (2006) Melatonin in the multi-oscillatory mammalian circadian world. Chronobiol Int23:39-51
144.
PevetPChalletE (2011) Melatonin: both master clock output and internal time-giver in the circadian clocks network. J Physiol105:170-182
145.
PitroskyBKirschRVivien-RoelsBGeorg-BentzICanguilhemBPevetP (1995) The photoperiodic response in Syrian hamster depends upon a melatonin-driven circadian rhythm of sensitivity to melatonin. J Neuroendocrinol7:889-895
146.
PitroskyBMasson-PevetMKirschRVivien-RoelsBCanguilhemBPévetP (1991) Effects of different doses and durations of melatonin infusions on plasma melatonin concentrations in pinealectomized Syrian hamsters: consequences at the level of sexual activity. J Pineal Res11:149-155
147.
PorterMRandallCBromageN (1996) The effect of pineal removal on circulating melatonin levels in Atlantic salmon parr. J Fish Biol48:1011-1013
148.
PrakashPLalorayaMPradeepKG (1998) Influence of a melatonin implant on the free radical load in avian thydroid and its relation with thyroid hormonogenesis. IUBMB Life46:1249-1258
149.
PrevoMJohnsonPChesterA (2000) Twenty-eight-day toxicity study of melatonin infused subcutaneously in rats via an osmotic pump. Int J Toxicol19:107-118
150.
QuispeRTrappschuhMGahrMGoymannW (2015) Towards more physiological manipulations of hormones in field studies: comparing the release dynamics of three kinds of testosterone implants, silastic tubing, time-release pellets and beeswax. Gen Comp Endocrinol212:100-105
151.
RajkumarRArgoCRodwayR (1989) Fertility of ewes given either melatonin or progestogen sponges. Veterinary Record124:215-217
152.
RalphCL (1976) Correlations of melatonin content in pineal gland, blood, and brain of some birds and mammals. Am Zool16:35-43
153.
RalphCMullDLynchHHedlundL (1971) A melatonin rhythm persists in rat pineals in darkness. Endocrinology89:1361-1366
154.
RavaultJPChesneauDOuvrayMLocatelliA (1996) Pineal microdialysis of the melatonin in conscious sheep: methodology, application to a diurnal rhythm and effect of isoproterenol. J Neuroendocrinol8:387-394
155.
ReiterRJ (1991) Melatonin: the chemical expression of darkness. Mol Cell Endocrinol79:C153-C158
156.
ReiterRJManchesterLTanD (2005) Melatonin in walnuts: influence on levels of melatonin and total antioxidant capacity of blood. Nutrition21:920-924
157.
ReiterRJRichardsonBAMatthewsSALaneSJFergusonBN (1983) Rhythms in immunoreactive melatonin in the retina and Harderian gland of rats: persistence after pinealectomy. Life Sci32:1229-1236
158.
ReiterRJRudeenPKSackmanJWVaughanMKJohnsonLYLittleJC (1977) Subcutaneous melatonin implants inhibit reproductive atrophy in male hamsters induced by daily melatonin injections. Endocr Res Commun4:35-44
159.
ReiterRJTanDXBurkhardtSManchesterLC (2001) Melatonin in plants. Nutr Rev59:286-290
160.
ReiterR. J.TanD. X.ManchesterL. C.SimopoulosA. P.MaldonadoM. D.FloresL. J.TerronM. P. (2007). Melatonin in edible plants (phytomelatonin): Identification, concentrations, bioavailability and proposed functions. World review of nutrition and dietetics, 97, 211.
161.
ReiterRVaughanMWaringP (1975) Studies on the minimal dosage of melatonin required to inhibit pineal antigonadotrophic activity in male golden hamsters. Horm Res6:258-267
162.
RichterCP (1922) A behavioristic study of the activity of the rat. Comp Psychol Monogr1, 2, 56.
163.
RikkertMORigaudA-S (2001) Melatonin in elderly patients with insomnia. A systematic review. Zeitschrift Für Gerontologie Und Geriatrie34:491-497
164.
RobinsonJKarschF (1987) Photoperiodic history and a changing melatonin pattern can determine the neuroendocrine response of the ewe to daylength. J Reprod Fertil80:159-165
165.
RobinsonJWallaceJAitkenRMcNeillyA (1993) Effect of chronic treatment with a GnRH agonist to suppress pulsatile LH secretion on the ability of exogenous melatonin to advance oestrous cyclicity in ewes. J Reprod Fertil99:601-608
166.
RojasHLekicTChenWJadhavVTitovaEMartinRTangJZhangJ (2008) The antioxidant effects of melatonin after intracerebral hemorrhage in rats. Acta Neurochir Suppl105:19-21
167.
RomanowiczKMisztalTGajewskaABarcikowskiB (2001) Daily GnRH and LH secretion in ewes is not modified by exogenous melatonin during seasonal anestrus. Acta Neurobiologiae Experimentalis61:289-298
168.
RonayneEEnrightWRocheJ (1993) Effects of continuous administration of gonadotropin-releasing hormone (GnRH) or a potent GnRH analogue on blood luteinizing hormone and testosterone concentrations in prepubertal bulls. Domest Anim Endocrinol10:179-189
169.
RozenboimIAharonyTYahavS (2002) The effect of melatonin administration on circulating plasma luteinizing hormone concentration in castrated White Leghorn roosters. Poultry Sci81:1354-1359
170.
RubioVSanchez-VazquezFMadridJ (2004) Oral administration of melatonin reduces food intake and modifies macronutrient selection in European sea bass (Dicentrarchus labrax, L.). J Pineal Res37:42-47
171.
RuppTLAceboCCarskadonMA (2007) Evening alcohol suppresses salivary melatonin in young adults. Chronobiol Int24:463-470
172.
Sae-TeawMJohnsJJohnsNPSubongkotS (2013) Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers. J Pineal Res55:58–64
173.
SallinenPMänttäriSLeskinenHVakkuriORuskoahoHSaarelaS (2008) Long-term postinfarction melatonin administration alters the expression of DHPR, RyR2, SERCA2, and MT2 and elevates the ANP level in the rat left ventricle. J Pineal Res45:61-69
174.
SanthiNThorneHCvan der VeenDRJohnsenSMillsSLHommesVSchlangenLJArcherSNDijkD (2012) The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans. J Pineal Res53:47-59
175.
SaylerAWolfsonA (1968) Influence of the pineal gland on gonadal maturation in the Japanese quail 1. Endocrinology83:1237-1246
176.
ScheupleinRJ (1976) Permeability of the skin: a review of major concepts and some new developments. J Investig Dermatol67:672-676
177.
SchuhlerSPitroskyBKirschRPévetP (2002) Entrainment of locomotor activity rhythm in pinealectomized adult Syrian hamsters by daily melatonin infusion. Behav Brain Res133:343-35
178.
SomaK (2006) Testosterone and aggression: Berthold, birds and beyond. J Neuroendocrinol18:543-551
179.
SpitschanMLucasRJBrownTM (2017) Chromatic clocks: Color opponency in non-image-forming visual function Review. Neurosci Biobehav Rev78:24-33
180.
StantonTDaleyJSalzmanS (1987) Prolongation of hibernation bout duration by continuous intracerebroventricular infusion of melatonin in hibernating ground squirrels. Brain Res413:350-355
181.
StetsonMHElliottJAGoldmanBD (1986) Maternal transfer of photoperiodic information influences the photoperiodic response of prepubertal Djungarian hamsters (Phodopus sungorus sungorus). Biol Reprod34:664-669
182.
StevensCEHumeID (2004) Comparative physiology of the vertebrate digestive system. Cambridge: Cambridge University Press.
183.
SuhnerASchlagenhaufPJohnsonRTschoppASteffenR (1998) Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int15:655-666
184.
TalbotJReiterR (1973) Influence of melatonin, 5-methoxytryptophol and pinealectomy on pituitary and plasma gonadotropin and prolactin levels in castrated adult male rats. Neuroendocrinology13:164-172
185.
TamarkinLBairdCJAlmeidaO (1985) Melatonin: a coordinating signal for mammalian reproduction?Science227:714-720
186.
TanTWattsSWDavisRP (2011) Drug delivery: enabling technology for drug discovery and development. iPRECIO Micro Infusion Pump: programmable, refillable, and implantable. Frontiers Pharmacol2:44
187.
TheeuwesF (1987) The Mini-Osmotic pump as a Tool in Chronobiology. In Chronobiotechnology and Chronobiological EngineeringSchevingLEHalbergFEhretCF eds, pp 61-64. Netherlands: Springer
188.
ThompsonDGodkeRNettT (1983) Effects of melatonin and thyrotropin releasing hormone on mares during the nonbreeding season. J Animal Sci56:668-677
189.
TrakulrungsiCReiterRTrakulrungsiWVaughanMWaring-EllisP (1979) Interaction of daily injections and subcutaneous reservoirs of melatonin on the reproductive physiology of female Syrian hamsters. Acta Endocrinologica91:59-69
190.
TranHTTTranPHLLeeB-J (2009) New findings on melatonin absorption and alterations by pharmaceutical excipients using the Ussing chamber technique with mounted rat gastrointestinal segments. Int J Pharm378:9-16
191.
UbukaTBentleyGEUkenaKWingfieldJCTsutsuiK (2005) Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain. Proc Natl Acad Sci U S A102:3052-3057
192.
UbukaTUkenaKSharpPJBentleyGETsutsuiK (2006) Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail. Endocrinology147:1187-1194
193.
UnderwoodH (1989) The pineal and melatonin: regulators of circadian function in lower vertebrates. Cell Mol Life Sci45:914-922
194.
UnderwoodHBinkleySSiopesTMosherK (1984) Melatonin rhythms in the eyes, pineal bodies, and blood of Japanese quail (Coturnix coturnix japonica). Gen Comp Endocrinol56:70-81
195.
UrquhartJFaraJWWillisKL (1984) Rate-controlled delivery systems in drug and hormone research. Ann Rev Pharmacol Toxicol24:199-236
196.
VakkuriORintamäkiHLeppäluotoJ (1985) Plasma and tissue concentrations of melatonin after midnight light exposure and pinealectomy in the pigeon. J Endocrinol105:263-268
197.
Van’t HofTJGwinnerE (1999) Influence of pinealectomy and pineal stalk deflection on circadian gastrointestinal tract melatonin rhythms in zebra finches (Taeniopygia guttata). J Biol Rhythms14:185-189
198.
VaughanGMReiterRJ (1986) Pineal dependence of the Syrian hamster’s nocturnal serum melatonin surge. J Pineal Res3:9-14
199.
VermaRKAroraSGargS (2004) Osmotic pumps in drug delivery. Crit Rev Ther Drug Carrier Syst21:477-520.
200.
Vivien-RoelsBMalanARettoriM-CDelagrangePJeanniotJ-PPévetP (1998) Daily variations in pineal melatonin concentrations in inbred and outbred mice. J Biol Rhythms13:403-409
201.
WarrenWSCassoneVM (1995) The pineal gland: photoreception and coupling of behavioral, metabolic, and cardiovascular circadian outputs. J Biol Rhythms10:64-79
202.
WaterhouseJMinorsDAtkinsonGBentonD (1997) Chronobiology and meal times: internal and external factors. Br J Nutrition77:S29-S38
203.
WeitzmanED (1976) Circadian rhythms and episodic hormone secretion in man. Ann Rev Med27:225-243
204.
WilsonFE (1991) Neither retinal nor pineal photoreceptors mediate photoperiodic control of seasonal reproduction in American tree sparrows (Spizella arborea). J Exp Zoology259:117-127
205.
WurtmanRJAxelrodJPhillipsLS (1963) Melatonin synthesis in the pineal gland: control by light. Science142:1071-1073
206.
YuHPangSTangP (1981) Increase in the level of retinal melatonin and persistence of its diurnal rhythm in rats after pinealectomy. J Endocrinol91:477-481
207.
ZhangH.CloudA. (2006, January). The Permeability Characteristics of Silicone Rubber. In SAMPE Fall Technical Conference (38th ISTC) 2006 Dallas, TX 38th.
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