Arterial ischemic stroke occurs as a result of abnormal clinical circumstances that alter hemostasis and cause thrombosis, either within a vessel or as an embolic event. Understanding normal hemostasis, including differences between children (developmental hemostasis) and adults, will provide background for determining the pathophysiology of stroke and potential treatments.
FurieBFurieB. Mechanisms of thrombus formation. N Engl J Med.2008;359:938–949.
2.
IgnarroLJBugaGMWoodKS. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987;84:9265–9269.
3.
PalmerRMJFerrigeAGMoncadaS. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987;327:524–526.
4.
MarcusAJBroekmanMJPinskyDJ. COX inhibitors and thromboregulation. New Engl J Med. 2002;347:1025–1026.
5.
MarcusAJBroekmanMJDrosopoulosJHF. Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection. Semin Thromb Hemost. 2005;31:234–246.
6.
DuboisCPanicot-DuboisLGainorJF. Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model. J Clin Invest. 2007;117:953–960.
7.
ManginPYapCLNonneC. Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood. 2006;107:4346–4353.
8.
RuggeriZM. Old concepts and new developments in the study of platelet aggregation. J Clin Invest. 2000;105:699–701.
9.
BergmeierWPiffathCLGoergeT. The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis. Proc Natl Acad Sci U S A. 2006;103:16900–16905.
10.
MassbergSGawazMGrunerS. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med. 2003;197:41–49.
11.
HoltkotterONieswandtBSmythN. Integrin alpha 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen. J Biol Chem. 2002;277:10789–10794.
12.
NieswandtBBrakebuschCBergmeierW. Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen. EMBO J. 2001;20:2120–2130.
13.
FalatiSLiuQGrossP. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J Exp Med. 2003;197:1585–1598.
14.
GiesenPLARauchUBohrmannB. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A. 1999;96:2311–2315.
15.
BachRRifkinDB. Expression of tissue factor procoagulant activity: regulation by cytosolic calcium. Proc Natl Acad Sci U S A. 1990;87:6995–6999.
16.
MaynardJRHeckmanCAPitlickFANemersonY. Association of tissue factor activity with the surface of cultured cells. J Clin Invest. 1975;55:814–824.
17.
BeckerRC. Cell-based models of coagulation: a paradigm in evolution. J Thromb Thrombolysis. 2005;20:65–68.
BurgessJKHotchkissKASuterC. Physical proximity and functional association of glycoprotein 1balpha and protein-disulfide isomerase on the platelet plasma membrane. J Biol Chem. 2000;275:9758–9766.
20.
ChenVMHoggPJ. Allosteric disulfide bonds in thrombosis and thrombolysis. J Thromb Haemost. 2006;4:2533–2541.
21.
EssexDWLiMMillerAFeinmanRD. Protein disulfide isomerase and sulfhydryl-dependent pathways in platelet activation. Biochemistry. 2001;40:6070–6075.
22.
DuXGuMWeiselJWNagaswamiC. Long range propagation of conformational changes in integrin alpha IIb beta 3. J Biol Chem. 1993;268:23087–23092.
23.
SitaruAGHolzhauerSSpeerCP. Neonatal platelets from cord blood and peripheral blood. Platelets. 2005;16:203–210.
24.
AndrewMPaesBJohnstonM. Development of the hemostatic system in the neonate and young infant. Am J Pediatr Hematol Oncol. 1990;12:95–104.
25.
AndrewMVeghPJohnstonM. Maturation of the hemostatic system during childhood. Blood. 1992;80:1998–2005.
26.
MassicottePLeakerMMarzinottoV. Enhanced thrombin regulation during warfarin therapy in children compared to adults. Thromb Haemost. 1998;80:570–574.
