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Abstract

Product (drug) shortages have had a significant impact on the healthcare system, particularly on patients and clinicians. This has been especially true with patients requiring parenteral nutrition (PN). The American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.) has dealt with PN product shortages in the past on behalf of its members and their patients. However, the shortage severity and duration have made dealing with the PN product shortages in 2010–2012 extremely challenging.

Keywords

electrolytes acid-base equilibrium minerals trace elements micronutrients nutritional support outcome assessment (health care)parenteral nutrition fat emulsions,intravenous vitamins amino acids parenteral nutrition solutions

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References

U.S. Food and Drug Administration. Frequently asked questions about drug shortages, http://www.fda.gov/Drugs/DrugSafety/DrugShortages/ucm050796.htm . Accessed June 16, 2011.

American Hospital Association Survey on Drug Shortages. June 2011. http://www.aha.org/content/11/drugshortagesurvey.pdf . Accessed August 25, 2011.

Kaakeh

Sweet

Reilly

. Impact of drug shortages on U.S. health systems. Am J Health Syst Pharm. 2011;68:1811-1819.

Office of the Press Secretary. We can’t wait: Obama administration takes action to reduce prescription drug shortages, fight price gouging. http://www .whitehouse.gov/the-press-office/2011/10/31/we-can-t-wait-obama- administration-takes-action-reduce-prescription-drugObama executive order

Centers for Disease Control and Prevention. Deaths associated with thiamine-deficient total parenteral nutrition. MMWR Morb Mortal Wkly Rep. 1989;38:43-46.

Kudsk

Holcombe

Bernstein

. Shortage of intravenous multivitamin solution in the United States [letter]. N Engl J Med. 1997;337:54-55.

Holcombe

Andris

Brooks

Houston

Plogsted

. Parenteral nutrition electrolyte/mineral product shortage considerations. JPEN J Parenter Enteral Nutr. 2011;35:434-436.

Institute for Safe Medication Practices (ISMP). Drug shortages: national survey reveals high level of frustration, low level of safety. ISMP Medication Safety Alert. 2010;15(19):1-5. http://www.ismp.org/Newsletters/acutecare/articles/20100923.asp

U.S. Food and Drug Administration (FDA). Meds IV pharmacy, IV compounded products recall: outbreak of Serratia marcescens bacteremia in Alabama hospitals. March 30, 2011. www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm249099.htm . Accessed August 27, 2011.

10.

Sacks

Rough

Kudsk

. Frequency and severity of harm of medication errors related to the parenteral nutrition process in a large university teaching hospital. Pharmacotherapy. 2009;29:966-974.

11.

A.S.P.E.N. Shortage Subcommittee of Clinical Practice Committee. Parenteral nutrition trace element product shortage considerations. http://www.nutritioncare.org/News/Parenteral_Nutrition_Trace_Element_Product_Shortage_Considerations

12.

Kochevar

Guenter

Holcombe

Malone

Mirtallo

; A.S.P.E.N. Board of Directors and Task Force on Parenteral Nutrition Standardization. A.S.P.E.N. statement on parenteral nutrition standardization. JPEN J Parenter Enteral Nutr. 2007; 31:441-418.