Abstract
Objective
To study the natural history of nasal carriage of
Setting
A teaching hospital single-center study.
Design
A prospective cohort study in prevalent continuous ambulatory peritoneal dialysis (CAPD) patients.
Patients
153 patients (76 male, 77 female; mean age 46 years) with a mean duration of CAPD of 2.4 years.
Methods
Nasal swabs were taken at approximately 2month intervals over the mean period of follow-up of 22.6 months and cultured for SA.
Results
An average of 69% of patients received systemic antibiotics for therapy of ESI, peritonitis, and other infections during the period of the study, but none received local nasal antibiotics. Four groups of patients were identified according to their nasal carriage history: chronic, intermittent, occasional, and noncarriers. The intermittent and chronic carriers had significantly higher SA ESI than the occasional and non carrier groups. The intermittent group also had the highest percentage of non-SA ES infections.
Conclusion
Although this study shows that only half of our CAPD patients with nasal carriage were at risk of developing ESI, we recommend that patients with a positive nasal swab at the start of CAPD therapy should be treated with nasal antibiotics or local antibiotics at the exit site.
Get full access to this article
View all access options for this article.