Two cases of missing children in Portugal (Joana and Maddie) have recently highlighted the dilemmas and contingencies associated with the technology of “genetic fingerprinting” for forensic purposes in the context of criminal investigations. The purpose of this article is to analyze the popular press’s discourses and representations around forensic genetics in the context of those two highly mediatized criminal investigation cases. The symbolical construction and representation of forensic genetics by the media presents a form of public exposure to beliefs on forensic genetics’ characteristics and potential. These are blended with popular cultural contexts that are constructed with reference to images of a super-science which may carry consequences in the public understanding of forensic science. The media coverage of both cases and their actual disclosure resembles the patterns of a CSI effect, insofar as real science’s capabilities and limitations are placed against fictionalized representations of forensic science.