This article deals with the equivalent elastic and piezoelectric constants of macro-fiber composite patches. Two types of macro-fiber composite patches, macro-fiber composite-d31 and macro-fiber composite-d33, are considered. The former one is dominated by the d31 effect, while the latter one mainly uses the d33 effect. First, based on the representative volume element technique, homogenized elastic and piezoelectric constants of those fiber-based substrate layers in macro-fiber composite patches are obtained through linear mixing rules. Second, using the obtained homogenized constants for fiber-based substrate layers, the overall elastic and piezoelectric constants of macro-fiber composite patches are obtained by modeling of multi-layer laminated macro-fiber composites based on the Reissner–Mindlin hypothesis. Finally, the homogenized overall material constants of macro-fiber composite patches are used to evaluate the structural behavior of macro-fiber composite bonded smart structures. The results calculated by homogenized constants are compared with those obtained by multi-substrate-layer modeling approach, as well as with those reported in the literature.