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Abstract

Ion channels no longer belong to students of the neuron. The development of the patch- clamp technique has triggered an avalanche of ion channel studies extending far beyond the initial investigations that tended to focus on neuronal excitability. Studies of basic cell properties, even in cells other than neurons, now routinely include the evaluation of a cell's electrophysiological features and have yielded a large and growing database con cerning the electrophysiological properties of inexcitable cells. These include such cells as fibroblasts, macrophages, glial cells, bone cells, epithelial cells, and even plant cells, to name but a few, and the electrophysiological properties of these cells are as wide ranging as their cell functions and tissue origins. The Neuroscientist 1:64-67, 1995

Keywords

KEY WORDS Ion channel Patch-clamp Glia Epithelium Lymphocyte Ion homeostasis,Proliferation

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References

Smith PR , Benos DJ Epithelial Na+ channels. Ann Rev Physiol 1991;53: 509-530.

Horisberger JD , Canessa C. , Rossier BC The epithelial sodium channel: recent developments . Cell Physiol Biochem 1993; 3:283-294.

Gogelein H. Chloride channels in epithelia. Biochim Biophys Acta 1988;947: 521-547.

Higgins CF Cystic fibrosis transmembrane conductance regulator (CFTR). Review . Br Med Bull 1992;48:754-765.

Cahalan MD , Chandy KG , Grissmer S. Potassium channels in development, activation, and disease in T lymphocytes . Curr Top Membr 1991;39:357-394.

DeCoursey TE , Chandy G. , Gupta S. , Cahalan MD Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis ? Nature 1984;307:465-468.

Gardner P. Patch clamp studies of lymphocyte activation. Review. Annu Rev Immunol 1990;8:231-252.

Gallin EK Ion channels in leukocytes. Review. Physiol Rev 1991;71:775-811.

Laxminarayana D. , Berrada A. , Kammer GM Early events of human T lymphocyte activation are associated with type I protein kinase A activity . J Clin Invest 1993;92:2207-2214.

10.

Levitan IB Modulation of ion channels in neurons and other cells. Ann Rev Neurosci 1988;11:119-136.

11.

Kuffler SW , Potter DD Glia in the leech central nervous system: physiological properties and neuron-glia relationship. J Neurophysiol 1964;27:290-320.

12.

Orkand RK , Nicholls JG , Kuffler SW Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia. J Neurophysiol 1966;29:788-806.

13.

Kuffler SW , Nicholls JG , Orkand RK Physiological properties of glial cells in the central nervous system of amphibia . J Neurophysiol 1966;29:768-787.

14.

Chiu SY , Schrager P. , Ritchie JM Neuronal-type Na+ and K+ channels in rabbit cultured Schwann cells. Nature 1984; 311:156-157.

15.

Gray Pta , Ritchie JM Ion channels in Schwann and glial cells. TINS 1985; 8:411-415.

16.

Ritchie JM Voltage-gated ion channels in Schwann cells and glia. TINS 1992; 15:345-351.

17.

Chiu SY Functions and distribution of voltage-gated sodium and potassium channels in mammalian Schwann cells. Glia 1991;4:541-558.

18.

Chiu SY Differential expression of sodium channels in acutely isolated myelinating and non-myelinating Schwann cells of rabbits. J Physiol (Lond) 1993;470:485-499.

19.

Barres BA , Chun Lly , Corey DP Ion channels in vertebrate glia. Annu Rev Neurosci 1990;13:441-474.

20.

Sontheimer H. Voltage-dependent ion channels in glial cells . Glia 1994;11: 156-172.

21.

Sontheimer H. , Waxman SG Expression of voltage-activated ion channels by astrocytes and oligodendrocytes in the hippocampal slice. J Neurophysiol 1993;70: 1863-1873.

22.

Orkand RK Glial cells. In: Brookhardt J , Mountcastle V , editors. Handbook of physiology . Washington, DC: Am Physiol Soc 1977;855-875.

23.

Newman EA Regional specialisation of retinal glial cell membrane. Nature 1984;309:155-157.

24.

Karwoski CJ , Lu H-K. , Newman EA Spatial buffering of light-evoked potassium increases by retinal Muller (glial) cells. Science 1989;244:578-580.

25.

Gautron S. , Dossantos G. , Pintohenrique D. , Koulakoff A. , Gros F. , Berwald-Netter Y. The glial voltage-gated sodium channel-cell-specific and tissue-specific messenger RNA expression. PNAS 1992;89: 7272-7276.

26.

Sontheimer H. , Fernandez-Marques E. , Ullrich N. , Pappas CA , Waxman SG Astrocyte Na + channels are required for maintenance of Na+/K+-ATPase activity. J Neurosci 1994;14:2464-2475.

27.

Munson Jr R. , Westermark B. , Glaser L. Tetrodotoxin-sensitive sodium channels in normal human fibroblasts and normal glia-like cells. PNAS 1979;76:6425-6429.

28.

Ypey DL , Weidema AF , Hold KM , et al. Voltage, calcium, and stretch activated ionic channels and intracellular calcium in bone cells. J Bone Miner Res 1992 ;7(Suppl 2):S377-S387.

29.

Rae JL Ion channels in ocular epithelia. Review. Invest Ophthalmol Vis Sci 1993;34:2608-2612.

30.

Thio CL , Waxman SG , Sontheimer H. Ion channels in spinal cord astrocytes in vitro: III. Modulation of channel expression by co-culture with neurons and neuron-conditioned medium . J Neurophysiol 1993;69:819-831.

31.

Barres BA , Koroshetz WJ , Chun Lly , Corey DP Ion channel expression by white matter glia: the type-1 astrocyte . Neuron 1990;5:527-544.

32.

Corvalan V. , Cole R. , deVellis J. , Hagiwara S. Neuronal modulation of calcium channel activity in cultured rat astrocytes. PNAS 1990;87:4345-4348.

33.

Negulyaev YA , Vedernikova EA Sodium-selective channels in membranes of rat macrophages. J Membr Biol 1994;138:37-45.

Ion Channels in Inexcitable Cells

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