In the concluding remarks I summarise my personal ‘take home’ messages and also yet to be answered questions from this timely and informative European Charcot Foundation Symposium.
PatyDW
. (1993) Interferon beta-lb is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized double-blind, placebo-controlled trial. Neurology43: 662-667.
2.
The IFNB Multiple Sclerosis Study Group. (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology43: 655-661.
3.
JacobsL
. (1994) Results of a phase III trial of intramuscular recombinant beta interferon as treatment for multiple sclerosis, (abstract). Ann Neurol36: 259.
4.
EbersGC. (1994) Treatment of multiple sclerosis. Lancet343: 275-279.
JohnsonHM,
. (1994) How interferons fight disease. Sci Am40-47.
7.
ArnasonBGW. (1993) Interferon beta in multiple sclerosis. Neurology43: 641-643.
8.
NoronhaA, ToscasA, JensenMA. (1992) Contrasting effects of alpha, beta, and gamma interferons on nonspecific suppressor function in multiple sclerosis. Ann Neurol31: 103-106.
9.
PanitchHS. (1992) Interferons in multiple sclerosis: a review of the evidence. Drugs44: 946-962.
10.
LiberatiAM
. (1994) Double-blind randomized phase I study on the clinical tolerance and pharmacodynamics of natural and recombinant interferon-beta given intravenously. J Interferon Res14: 61-69.
DurelliL
. (1994) Chronic systemic high-dose recombinant interferon alpha-2a reduces exacerbation rate, MRI signs of disease activity, and lymphocyte interferon gamma production in relapsing-remitting multiple sclerosis. Neurology44: 406—413.
13.
PalmisanoL
. (1990) Comparative pharmacokinetics and pharmacodynamics of beta interferon following 3 routes of administration (abstract). J Interferon Res (ISIR meeting on the interferon system), 10 (suppl.).
14.
BrodSA, BurnsDK. (1994) Suppression of relapsing experimental autoimmune encephalomyelitis in the SJL/ J mouse by oral administration of type 1 interferons. Neurology44: 1144-1148.
15.
McDonaldWI, MillerDH, ThompsonAJ. (1994) Are magnetic resonance findings predictive of clinical out-come in therapeutic trials in multiple sclerosis? The dilemma of Interferon-beta. Ann Neurol36: 14-18.
16.
JohnsonK. (1994) Abstract. Ann Neurol36: 259.
17.
British and Dutch Multiple Sclerosis Azathioprine Trial Group. (1988) Double-masked trial of azathioprine in multiple sclerosis. Lancetii179-183.
18.
KapposL
. (1988) Cyclosporine vs azathioprine in the long-term treatment of MS-results of the German multicenter study. Ann Neurol23: 56-63.