Increasing numbers of nurses are moving from their direct clinical base to take up posts as clinical research nurses. However, although there are published guidelines about their role responsibilities, little is written about the reality of the role. This paper offers an experiential account into the variety of responsibilities undertaken by CRNs, highlighting the extended role that experienced CRNs may undertake, the transferable skills exhibited and the extent to which traditional boundaries between professionals can continue to be challenged. Role remits are examined in an attempt to show that not only do CRNs possess many of the skills that are highly regarded and respected in specialised clinical nursing but also that they may be well placed within the profession to assist in building the evidence base for practice as nursing continues to develop.