The association of Down's syndrome and autism is becoming increasingly recognized. We describe three individuals with this dual diagnosis and emphasize the need to consider it particularly in people with abnormalities in their social, communication and language development that are discrepant for their overall level of learning disability. The need to make this diagnosis as early as possible is important to ensure appropriate education and future service provision.
BOLTON, P. , MACDONALD, H., PICKLES, A., RIOS, P., GOODE, M., CROWSON, M., BAILEY, A. & RUTTER, M. (1994) 'A Case-Control Family History Study of Autism', Journal of Child Psychology and Psychiatry35: 877-900.
2.
COOPER, S. A. & COLLACOTT, R. A. (1994) 'Clinical Features and Diagnostic Criteria of Depression in Down's Syndrome', British Journal of Psychiatry165: 399-403.
3.
FOMBONNE, E. (1997) 'Prevalence of Autistic Spectrum Disorders in the UK', Autism1(2): 227-229.
4.
GATH, A. & GUMLEY, D. (1986) 'Behaviour Problems in Retarded Children with Special Reference to Down's Syndrome', British Journal of Psychiatry149: 156-161.
5.
GHAZIUDDIN, M. (1997) 'Autism in Down's Syndrome: Family History Correlates', Journal of Intellectual Disability Research41: 87-91.
6.
GHAZIUDDIN, M. & TSAI, L. Y. (1991) 'Depression in Autistic Disorder (Depressive Illness in a Patient with Down's Syndrome and Autism)', British Journal of Psychiatry159: 721-723.
7.
GHAZIUDDIN, M. , TSAI, L.Y. & GHAZIUDDIN, N. (1992) 'Autism in Down's Syndrome: Presentation and Diagnosis', Journal of Intellectual Disability Research36: 449-456.
8.
GILLBERG, C. (1991) 'The Treatment of Epilepsy in Autism', Journal of Autism and Developmental Disorders21: 61-77.
9.
GILLBERG, C. , PERSSON, E., GRUFMAN, N. & THEMNER, U. (1986) 'Psychiatric Disorders in Mildly and Severely Mentally Retarded Urban Children and Adolescents: Epidemiological Aspects', British Joumnal of Psychiatry149: 68-74.
10.
HOWLIN, P. , WING, L. & GOULD, J. (1995) 'The Recognition of Autism in Children with Down's Syndrome: Implications for Intervention and Some Speculations about Pathology', Developmental Medicine and Child Neurology37: 398-414.
11.
KENT, L. , EVANS, J., PAUL, M. & SHARP, M. (submitted) 'The Co-morbidity of Autistic Spectrum Disorders in Children with Down's Syndrome'.
12.
LAINHART, J.E. & FOLSTEIN, S.E. (1994) 'Affective Disorders in People with Autism: A Review of Published Cases', Journal of Autism and Developmental Disorders24(5): 587-601.
13.
LORD, C. , RUTTER, M. & LE COUTEUR, A. (1994) 'Autism Diagnostic Interview-Revised: A Revised Version of a Diagnostic Interview for Caregivers of Individuals with Possible Pervasive Developmental Disorder, Journal of Autism and Developmental Disorders24: 659-685.
14.
LUND, J. (1988) Psychiatric Aspects of Down's Syndrome', Acta Psychiatrica Scandinavica78: 369-374.
15.
PRASHER, V. P. & CLARKE, D. J. (1996) 'Case Report: Challenging Behaviour in a Young Adult with Down's Syndrome and Autism', British Journal of Learning Disabilities24: 167-169.
16.
RUTTER, M. & SCHOPLER, E. (1988) 'Autism and Pervasive Developmental Disorders', in M. RUTTER, A. H. TUMAANDI. S. LANN (eds) Assessment and Diagnosis in Child Psychopathology. London: David Fulton.
17.
SAFSTROM, C.E. , PAXTOT, O.F., GILMORE, H.E. & WISNIEWSKI, K.E. (1991) 'Seizures in Children with Down's Syndrome: Aetiology, Characteristics and Outcome', Developmental Medicine and Child Neurology33: 191-200.
18.
TURK, J. (1992) 'Children with Down's Syndrome and Fragile X Syndrome: A Comparison Study', in Society for Study of Behavioural Phenotypes: 2nd Symposium Abstracts. Oxford: SSBP.
19.
WAKABAYASHI, S. (1979) 'A Case of Infantile Autism Associated with Down's Syndrome', Joumnal of Autism and Developmental Disorders9: 31-36.
20.
WING, L. (1996) 'Autistic Spectrum Disorders: No Evidence For or Against an Increase in Prevalence', British Medical Journal312: 327-328.
21.
WORLD HEALTH ORGANIZATION (1992) The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.