Cognitive impairment is a core Feature oF schizophrenia. The evolution oF cognitive impairment over the liFe span may clariFy whether schizophrenia is best characterized as a neurodevelopmental or neurodegenerative disorder. Children who later develop schizophrenia show delayed language acquisition, intellectual impairment, and poorer academic perFormance than peers. These premorbid intellectual deFicits may worsen beFore illness onset. Although patients show pervasive intellectual impairment at First episode, this deFicit does not appear to worsen through middle age. Gerontological patients remain poorly characterized, but a subset oF chronic, institutionalized patients may show Further intellectual and Functional decline in old age. From a cognitive perspective, schizophrenia may be best viewed as a neurodevelopmental disorder initiated by genetic or environmental Factors in the prenatal period. These early changes may contribute to premorbid cognitive impairment and to subsequent disturbances oF neural connectivity and transmission.
Tsuang M.Schizophrenia: genes and environment. Biol Psychiatry. 2004;47:210-220.
2.
Saha S., Chant D., Welham J., McGrath J.A systematic review oF the prevalence oF schizophrenia. PLoS Med.2005;2:e141.
3.
Bromet EJ, Fennig S.Epidemiology and natural history oF schizophrenia. Biol Psychiatry . 1999;46:871-881.
4.
Sullivan PFThe genetics oF schizophrenia. PLoS Med.2005 ;2:e212.
5.
HaFner H., an der Heiden W.The course oF schizophrenia in the light oF modern Follow-up studies: the ABC and WHO studies. Eur Arch Psychiatry Clin Neurosci. 1999;249(suppl 4):14-26.
6.
Tsuang MT, Woolson RF, Fleming JALong-term outcome oF major psychosis: schizophrenic and aFFective disorders compared with psychiatrically symptom-Free surgical conditions. Arch Gen Psychiatry. 1979;39:1295-1301.
7.
Green MFWhat are the Functional consequences oF neurocognitive deFicits in schizophrenia?Am J Psychiatry.1998;155:1080-1086.
8.
KeeFe RS, Eesley CE, Poe MPDeFining a cognitive Function decrement in schizophrenia. Biol Psychiatry. 2005;57:688-691.
9.
Nestor PG, O'Donnell BF. The mind adriFt: attention dysregulation in schizophrenia. In: Parasuraman R, ed. The Attentive Brain. Boston: MIT Press; 1998;527-546.
10.
Weinberger DRSchizophrenia as a neurodevelopmental disorder . In: Hirsch SR, Weinberger DR, eds. Schizophrenia. Cambridge, MA: Blackwell; 1995:293-323.
11.
Anderson JE , O'Donnell BF, McCarley RW, Shenton ME. Progressive changes in schizophrenia: do they exist and what do they mean?Restor Neurol Neurosci.1998;12:175-184.
12.
Cohen J.Statistical Power Analysis for the Social Sciences. 2nd ed. Hillsdale, NJ: LEA; 1988.
13.
Neale JM, Oltmanns TFSchizophrenia. New York NY: Wiley ; 1980.
14.
Aylward E., Walker E., Bettes B.Intelligence in schizophrenia: meta-analysis oF the research. Schizophr Bull. 1984;18:437-448.
15.
Kremen WS, Lyons MJ, Boake C., et al. A discordant twin study oF premorbid cognitive ability in schizophrenia . J Clin Exp Neuropsychol. 2006;28:208-224.
16.
Seidman LJ, Buka SL, Goldstein JM, Tsuang MTIntellectual decline in schizophrenia: evidence From a prospective birth cohort 28 year Follow up study. J Clin Exp Neuropsychol. 2006;28:225-242.
17.
Goldberg TE , Torrey EF, Gold JM, et al. Genetic risk oF neuropsychological impairment in schizophrenia: a study oF monozygotic twins discordant and concordant For the disorder. Schizophr Res. 1995;17:77-84.
18.
Cannon TD, Huttunen MO, Lonnqvist J., et al. The inheritance oF neuropsychological dysFunction in twins discordant For schizophrenia. Am J Hum Genet.2000;67: 369-382.
Holzman PSEye movements and the search For the essence oF schizophrenia. Brain Res Brain Res Rev.2000;3:350-356.
21.
Saykin AJ, Shtasel DL, Gur RE, et al. Neuropsychological deFicits in neuroleptic naive patients with First episode schizophrenia. Arch Gen Psychiatry. 1994;51:124-131.
22.
Bombin I., Arango C., Buchanan RWSigniFicance and meaning oF neurological signs in schizophrenia: two decades later. Schizophr Bull. 2005;31:962-977.
23.
Tuulio-Henriksson A., Partonen T., Suvisaari J., Haukka J., Lonnqvist J.Age at onset and cognitive Functioning in schizophrenia. Br J Psychiatry. 2004;185:215-219.
24.
Niendam TA, Bearden CE, Rosso IM, et al. A prospective study oF childhood neurocognitive Functioning in schizophrenic patients and their siblings. Am J Psychiatry.2003;160:2060-2062.
25.
Jones PB, Tarrant CJDevelopmental precursers and biological markers For schizophrenia and aFFective disorders: speciFicity and public health implications. Eur Arch Psychiatry Clin Neurosci.2000;205:286-291.
26.
Rabinowitz J., Reichenberg A., Weiser M., Mark M, Kaplan Z, Davidson M. Cognitive and behavioural Functioning in men with schizophrenia both beFore and shortly aFter First admission to hospital. Cross-sectional analysis. Br J Psychiatry . 2000;177:26-32.
27.
Zammit S., Allebeck P., David AS, et al. A longitudinal study oF premorbid IQ score and risk oF developing schizophrenia, bipolar disorder, severe depression, and other nonaFFective psychoses. Arch Gen Psychiatry. 2004;61:354-360.
28.
Caspi A., Reichenberg A., Weiser M., et al. Cognitive perFormance in schizophrenia patients assessed beFore and Following the First psychotic episode. Schizophr Res. 2003;65:87-94.
29.
Cosway R., Byrne M., ClaFFerty R., et al. Neuropsychological change in young people at high risk For schizophrenia: results From the First two neuropsychological assessments oF the Edinburgh High Risk Study. Psychol Med.2000;30:1111-1121.
30.
Russell AJ, Munro JC, Jones PB, Hemsley DR, Murray RMSchizophrenia and the myth oF intellectual decline. Am J Psychiatry.1997;154:635-639.
31.
Bilder RM, Reiter G., Bates J., et al. Cognitive development in schizophrenia: Follow-back From the First episode. J Clin Exp Neuropsychol. 2006 ;28:270-282.
32.
Fuller R., Nopoulos P., Arndt S., O'Leary D., Ho BC, Andreasen NCLongitudinal assessment oF premorbid cognitive Functioning in patients with schizophrenia through examination oF standardized scholastic test perFormance . Am J Psychiatry.2002;159:1183-1189.
33.
Sheitman BB, Murray MG, Snyder JA, et al. IQ scores oF treatment-resistant schizophrenia patients beFore and aFter the onset oF the illness. Schizophr Res. 2000;46: 203-207.
34.
Townsend LA, Norman MGCourse oF cognitive Functioning in First episode schizophrenia spectrum disorders . Expert Rev Neurother. 2004;4:61-68.
35.
Rund BRA review oF longitudinal studies oF cognitive Functions in schizophrenia patients . Schizophr Bull. 1998;24:425-435.
36.
Stirling J. , White C., Lewis S., et al. Neurocognitive Function and outcome in First-episode schizophrenia: a 10-year Follow-up oF an epidemiological cohort. Schizophr Res. 2003;65:75-86.
37.
Hoff AL , Svetina C., Shields G., Steward J., DeLisi LETen year longitudinal study oF neuropsychological Functioning subsequent to a First episode oF schizophrenia. Schizophr Res. 2005;78:27-34.
38.
Heaton R., Paulsen JS, McAdams LA, et al. Neuropsychological deFicits in schizophrenics: relationship to age, chronicity and dementia. Arch Gen Psychiatry. 1994; 51:469-476.
39.
Hyde TM, Nawroz S., Goldberg TE, et al. Is there cognitive decline in schizophrenia? A cross-sectional study. Br J Psychiatry. 1994;164:494-500.
40.
Savla GN, Moore DJ, Roesch SC, Heaton RK, Jeste DV, Palmer BWAn evaluation oF longitudinal neurocognitive perFormance among middle-aged and older schizophrenia subjects: use oF mixed-model analyses. Schizophr Res. 2006;83:215-223.
41.
Wadington JL , YousseF HA. Cognitive dysFunction in chronic schizophrenia Followed prospectively over 10 years and its longitudinal relationship to the emergence oF tardive dyskinesia. Psychol Med.1996;26:681-688.
42.
Harvey PD, KeeFe RS. Studies oF cognitive change in patients with schizophrenia Following novel antipsychotic treatment. Am J Psychiatry.2001;158:176-184.
43.
KeeFe RS, Mohs RC, Losonczy MF, et al. Characteristics oF very poor outcome in schizophrenia. Am J Psychiatry.1987;144:889-895.
44.
Friedman JI , Harvey PD, Coleman T., et al. Six-year Follow-up study oF cognitive and Functional status across the liFespan in schizophrenia: a comparison with Alzheimer's disease and normal aging. Am J Psychiatry.2001;158:1441-1448.
45.
Bowie C., Tsapela I., Friedman J., Pareella M., White L., Harvey PDThe longitudinal course oF thought disorder in geriatric patients with chronic schizophrenia. Am J Psychiatry.2005;162:793-795.
46.
Kurtz MMNeurocognitive impairment across the liFespan in schizophrenia: an update . Schizophr Res. 2005;74:15-26.
47.
Hegarty JD, Baldessarini RJ, Tohen M., Waternaux C., Oepen G.One hundred years oF schizophrenia: a meta-analysis oF the outcome literature . Am J Psychiatry.1994;141:1409-1416.
48.
Zukerman M.Vulnerability to Psychopathology: A Biosocial Model. Washington, DC: American Psychological Association; 1999:319-412.
49.
Lieberman JA , Stroup TS, McEvoy JP, et al. Clinical Antipsychotic Trials oF Intervention EFFectiveness (CATIE) Investigators. EFFectiveness oF antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med.2005;353:1209-1223.
50.
Hagan JJ, Jones DNPredicting drug eFFicacy For cognitive deFicits in schizophrenia. Schizophr Bull. 2005; 31:830-853.
51.
Mishara AL, Goldberg TEA meta-analysis and critical review oF the eFFects oF conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book. Biol Psychiatry. 2004;55:1013-1022.
52.
Penn DL, Mueser KTResearch update on the psychosocial treatment oF schizophrenia. Am J Psychiatry.1996;153:607-617.
53.
Bustillo J. , Lauriello J., Horan W., Keith S.The psychosocial treatment oF schizophrenia: an update. Am J Psychiatry.2001;158:163-175.
54.
Woods BTIs schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism. Am J Psychiatry.1998 ;155:1661-1670.
55.
Teipel SJ, Hampel H.Neuroanatomy oF Down syndrome in vivo: a model oF preclinical Alzheimer's disease. Behav Genet.2006;36:405-415.
56.
Bogerts B.The neuropathology oF schizophrenic diseases: historical aspects and present knowledge. Eur Arch Psychiatry Clin Neurosci.1999;249(suppl 4):2-13.
57.
Rapoport JL , Addington AM, Frangou S., Psych MRThe neurodevelopmental model oF schizophrenia: update 2005. Mol Psychiatry. 2005;10:434-449.
58.
Purohit DP, Perl DP, Haroutunian V., Powchik P., Davidson M., Davis KLAlzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia: a postmortem neuropathologic study oF 100 cases. Arch Gen Psychiatry. 1998;55:205-211.
59.
Selemon LD, Goldman-Rakic PSThe reduced neuropil hypothesis: a circuit based model oF schizophrenia. Biol Psychiatry. 1999;45:17-25.
60.
Lewis DA, Levitt P.Schizophrenia as a disorder oF neuro-development. Annu Rev Neurosci.2002;25:409-432.
