Vitamin B12 deficiencies are common in individuals consuming plant-predominant diets, including those who consume diary and/or eggs. Deficiencies can lead to megaloblastic anemia and peripheral neuropathy, among other multi-system manifestations. The prevalence, assessment and prevention of vitamin B12 deficiency in patients following plant-predominant diets will be discussed.
RizzoGLaganaASRapisardaAMC, et al. Vitamin B12 among vegetarians: status, assessment and supplementation. Nutrients. 2016;8:767. doi:10.3390/nu8120767
10.
HerrmannWSchorrHObeidRGeiselJ. Vitamin B12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperchomocysteinemia in vegetarians. Am J Clin Nutr. 2003;78:131-136.
11.
HerrmannWGeiselJ. Vegetarian lifestyle and monitoring of vitamin B12 status. Clin Chim Acta. 2002;326:47-59.
12.
WokesFBadenochJSinclairHM. Human dietary deficiency of vitamin B12. Am J Clin Nutr. 1955;3:375-382.
13.
DhopeshwarkarGATrivediJCKulkarniBSSatoskarRSLewisRA. The effect of vegetarianism and antibiotics upon proteins and vitamin B12 in the blood. Br J Nutr. 1956;10:105-110.
14.
PawlakRLesterSEBabatundeT. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. Eur J Clin Nutr. 2014;68:541-548.
15.
AnthonyAC. Vegetarianism and vitamin B12 (cobalamin) deficiency. Am J Clin Nutr. 2003;78:3-6.
16.
MillerDRSpeckerBLHoML, et al. Vitamin B12 status in a macrobiotic community. Am J Clin Nutr. 2001;74:233-241.
17.
Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B(6), Folate, Vitamin B(12), Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998. Available athttps://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/. Accessed April 28, 2022.
18.
DonaldsonMS. Metabolic vitamin B12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast or probiotic supplements. Ann Nutr Metab. 2000;44:229-234.
19.
The American Dietitic Association. Position of the academy of nutrition and dietetics: vegetarian diets. J Acad Nutr Diet. 2015;116:1970-1980.
20.
AdamsJF. The urinary excretion and tissue retention of cyanocobalamin by subjects given repeated parenteral doses. J Clin Pathol. 1964;17:31-38.
21.
CarmelR. How I treat cobalamin (vitamin B12) deficiency. Blood. 2008;112:2214-2221.
22.
Vidal-AlaballJButlerCCCannings-JohnR, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005;3:CD004655.
23.
HerbertV. Vitamin B12: plant sources, requirements, and assay. Am J Clin Nutr. 1988;48:852-858.
24.
HerrmannWObeidRSchorrH, et al. Enhanced bone metabolism in vegetarians- the role of vitamin B12 deficiency. Clin Chem Lab Med. 2009;47:1281-1287.
25.
SelhubJJacquesPFRosenbergIH, et al. Serum total homocysteine concentrations in the third national health and nutrition examination survey (1991-1994): population reference range and contribution of vitamin status to high serum concentrations. Ann Intern Med. 1999;131:331-339.
