Objective: This systematic review and meta-analysis sought to assess the impact of pregnancy on bioprosthetic valve (BPV) structural valve deterioration.
Methods: We searched Ovid MEDLINE, Scopus, Clinicaltrials.gov, and Cochrane Library from inception through October 17, 2022. We included all studies that compared patients with BPV with and without a pregnancy history. The initial search yielded 1748 unique citations that were screened in Covidence by two independent reviewers. Our outcome of interest was structural valve deterioration.
Results: We performed random-effects meta-analyses from nine eligible studies. Meta-analysis of 321 individuals with a pregnancy history and 987 control individuals without pregnancy showed there was an increased odds in development of structural valve deterioration among those with a pregnancy history (OR 2.34, 95% CI 1.40–3.89) with an I2 of 59.8%.
Conclusions: A pregnancy history was associated with an increased risk of structural valve deterioration; however, further research is needed due to the heterogeneity of results.
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
0.00 MB0.02 MB 0.01 MB 0.02 MB 
