Applicability Results of a Nonlinear Model-Based Robust Blood Glucose Control Algorithm

Abstract

Introduction:

Generating optimal control algorithms for an artificial pancreas is an intensively researched problem. The available models are all nonlinear and rather complex. Model predictive control or run-to-run-based methodologies have proven to be efficient solutions for individualized treatment of type 1 diabetes mellitus (T1DM). However, the controller has to ensure safety and stability under all circumstances. Robust control methods seek to provide this safety and guarantee to handle even the worst-case situations and, hence, to generalize and complement results obtained by individualized control algorithms. Methods: Modern robust (e.g., H_inf) control is a linear model-based methodology that we have combined with the nonlinear model-based linear parameter varying technique. The control algorithm was designed on the high-complexity modified nonlinear glucose-insulin model of Sorensen, and it was compared step-by-step with linear model-based H_inf control results published in the literature. The applicability of the developed algorithm was tested first on a control cohort of 10 healthy persons' oral glucose tolerance test results and then on a large meal absorption profile adapted from the literature. In the latter case, two preliminary virtual patients were generated based on 1–1 week real continuous glucose monitor measurements.

Results:

We have found that the algorithm avoids hypoglycemia (not caused by physical activity or stress) independently from the considered absorption profiles.

Conclusion:

Use of hard constraints proved their efficiency in fitting blood glucose level within a defined interval. However, in the future, more data of different T1DM patients will be collected and tested, including dynamic absorption model and in silico tests on validated simulators.