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Abstract

A current medical challenge is the replacement of tissue which can be thought of in terms of bone tissue engineering approaches. The key problem in bone tissue engineering lies in associating bone stem cells with material supports or scaffolds that can be implanted in a patient. Beside bone tissue engineering approaches, these types of materials are used daily in orthopaedics and dental practice as permanent or transitory implants such as ceramic bone filling materials or metallic prostheses. Consequently, it is essential to better understand how bone cells interact with materials. For several years, the current authors and others have developed in vitro studies in order to elucidate the mechanisms underlying the response of human bone cells to implant surfaces. This paper reviews the current state of knowledge and proposes future directions for research in this domain.

Keywords

surface topography surface chemistry cell adhesion cell proliferation cell differentiation protein adsorption bone implant roughness parameters

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References

Boyan

B. D.

Hummert

T. W.

Dean

D. D.

Schwartz

Role of material surfaces in regulating bone and cartilage cell response. Biomaterials 1996 17, 137–146

Brunette

D. M.

Chehroudi

The effects of the surface topography of micromachined titanium substrata on cell behavior in vitro and in vivo . J. Biomech. Engng 1999 121, 49–57

Anselme

Osteoblast adhesion on biomaterials. Biomaterials 2000 21, 667–681

Boyan

B. D.

Lohmann

C. H.

Dean

D. D.

Cochran

D. L.

Schwartz

Mechanisms involved in osteoblast response to implant surface morphology. Annu. Rev. Mater. Res. 2001 31, 357–371

Dalby

M. J.

Topographically induced direct cell mechanotransduction. Med. Engng Phys. 2005 27, 730–742

Siebers

M. C.

Ter Brugge

P. J.

Walboomers

X. F.

Jansen

J. A.

Integrins as linker proteins between osteoblasts and bone replacing materials. A critical review. Biomaterials 2005 26, 137–146

Wang

Tytell

J. D.

Ingber

D. E.

Mechanotransduction at a distance: Mechanically coupling the extracellular matrix with the nucleus. Nat. Rev. Mol. Cell Biol. 2009 10, 75–82

Starr

D. A.

A nuclear-envelope bridge positions nuclei and moves chromosomes. J. Cell Sci. 2009 122, 577–586

Gieni

R. S.

Hendzel

M. J.

Mechanotransduction from the ECM to the genome: Are the pieces now in place?

J. Cell Biochem. 2008 104, 1964–1987

10.

Curtis

A. S. G.

Dalby

M. J.

Gadegaard

Nanoprinting onto cells. J. R. Soc. Interface 2006 3, 393–398

11.

Wozniak

M. A.

Modzelewska

Kwong

Keely

P. J.

Focal adhesion regulation of cell behavior. Biochimica et Biophysica Acta 2004 1692, 103–119

12.

Biggs

M. J.

Richards

R. G.

McFarlane

Wilkinson

C. D.

Oreffo

R. O.

Dalby

M. J.

Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves. J. R. Soc. Interface 2008 5, 1231–1242

13.

Cukierman

Pankov

Yamada

K. M.

Cell interactions with three-dimensional matrices. Curr. Opin. Biotech. 2002 14, 633–639

14.

Baker

J. P.

Titus

M. A.

Myosins: Matching functions with motors. Curr. Opin. Cell Biol. 1998 10, 80–86

15.

Ingber

D. E.

Cellular mechanotransduction: Putting all the pieces together again. FASEB J. 2006 20, 811–827

16.

Trepat

Lenormand

Fredberg

J. J.

Universality in cell mechanics. Soft Matter 2008 4, 1750–1759

17.

Dalby

M. J.

Gadegaard

Curtis

A. S. G.

Oreffo

R. O. C.

Nanotopographical control of human osteoprogenitor differentiation. Curr. Stem Cell Res. Ther. 2007 2, 129–138

18.

Fujita

Ohshima

Iwata

Time-lapse observation of cell alignment on nanogrooved patterns. J. R. Soc. Interface 2009 6, S269–S277

19.

Meyer

Büchter

Wiesmann

H. P.

Joos

Jones

D. B.

Basic reactions of osteoblasts on structured material surfaces. Eur. Cells Mater. 2005 9, 39–49

20.

Anselme

Bigerelle

Modelling approach in cell/material interactions studies. Biomaterials 2006 27, 1187–1199

21.

Anselme

Bigerelle

Noel

Dufresne

Judas

Iost

Hardouin

Qualitative and quantitative study of human osteoblast adhesion on materials with various surface roughness. J. Biomed. Mater. Res. 2000 49, 155–166

22.

Anselme

Bigerelle

Statistical demonstration of the relative effect of surface chemistry and roughness on human osteoblast short-term adhesion. J. Mater. Sci., Mater. Med. 2006 17, 471–479

23.

Hallab

N. J.

Bundy

K. J.

O'Connor

Moses

R. L.

Jacobs

J. J.

Evaluation of metallic and polymeric biomaterial surface energy and surface roughness characteristics for directed cell adhesion. Tissue Engng 2001 7, 55–71

24.

Vitte

Benoliel

A. M.

Pierres

Bongrand

Is there a predictable relationship between surface physical-chemical properties and cell behaviour at the interface?

Eur. Cells Mater. 2004 7, 52–63

25.

Ponsonnet

Comte

Othmane

Lagneau

Charbonnier

Lissac

Jaffrezic

Effect of surface topography and chemistry on adhesion, orientation and growth of fibroblasts on nickel-titanium substrates. Mater. Sci. Engng C, Mater. Biol. Appl. 2002 21, 157–165

26.

Anselme

Linez

Bigerelle

le Maguer

Hardouin

Hildebrand

H. F.

Iost

Leroy

J.-M.

The relative influence of the topography and chemistry of Ti6Al4V surfaces on osteoblastic cell behaviour. Biomaterials 2000 21, 1567–1577

27.

Wirth

Grosgogeat

Lagneau

Jaffrezic-Renault

Ponsonnet

Biomaterial surface properties modulate in vitro rat calvaria osteoblasts response: Roughness and or chemistry?

Mater. Sci. Engng C, Mater. Biol. Appl. 2008 28, 990–1001

28.

dos Santos

E. A.

Farina

Soares

G. A.

Anselme

Chemical and topographical influence of hydroxyapatite and beta-tricalcium phosphate surfaces on human osteoblastic cell behavior. J. Biomed. Mater. Res. A 2009 89, 510–520

29.

Anselme

Bigerelle

Role of materials surface topography on mammalian cell response. Int. Mater. Rev. 2010, submitted.

30.

Ben-Ze'ev

The cytoskeleton in cancer cells. Biochimica et Biophysica Acta 1985 780, 197–212

31.

Davidson

Özçelik

Hasirci

Reiter

Anselme

Micro-structured surfaces cause severe but non-detrimental deformation of the cell nucleus. Adv. Mater. 2009 21, 3586–3590

32.

Davidson

Fromigue

Marie

Hasirci

Reiter

Anselme

Topographically induced self-deformation of the nuclei of cells: Dependence on cell type and proposed mechanisms. J. Mater. Sci., Mater. Med. 2010 31, 939–946

33.

Ochalek

Nordt

F. J.

Tullberg

Burger

M. M.

Correlation between cell deformability and metastatic potential in B16-F1 melanoma cell variants. Cancer Res. 1988 48, 5124–5128

34.

Guck

Schinkinger

Lincoln

Wottawah

Ebert

Romeyke

Lenz

Erickson

H. M.

Ananthakrishnan

Mitchell

Kas

Ulvick

Bilby

Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys. J. 2005 88, 3689–3698

35.

Reddy

K. L.

Zullo

J. M.

Bertolino

Singh

Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 2008 452, 243–247

36.

Sexton

Schober

Fraser

Gasser

S. M.

Gene regulation through nuclear organization. Nat. Struct. Mol. Biol. 2007 14, 1049–1055

37.

Curtis

A. S. G.

Wilkinson

Topographical control of cells. Biomaterials 1997 18, 1573–1583

38.

Sanz-Herrera

J. A.

Moreo

Garcia-Aznar

J. M.

Doblare

On the effect of substrate curvature on cell mechanics. Biomaterials 2009 30, 6674–6686

39.

Ingber

D. E.

Tensegrity: The architectural basis of cellular mechanotransduction. Annu. Rev. Physiol. 1997 59, 575–599

40.

Dunn

G. A.

Heath

J. P.

A new hypothesis of contact guidance in tissue cells. Exp. Cell Res. 1976 101, 1–14

41.

W. T.

Chu

I. M.

Yang

J. Y.

Lin

C. D.

The geometric pattern of a pillared substrate influences the cell-process distribution and shapes of fibroblasts. Micron 2006 37, 699–706

42.

Park

J. Y.

Lee

D. H.

Lee

E. J.

Lee

S. H.

Study of cellular behaviors on concave and convex microstructures fabricated from elastic PDMS membranes. Lab Chip 2009 9, 2043–2049

43.

Blackshaw

S. E.

Thompson

S. W.

Hyperpolarizing responses to stretch in sensory neurones innervating leech body wall muscle. J. Physiol. 1988 396, 121–137

44.

Chen

Mwenifumbo

Langhammer

McGovern

Beye

Soboyejo

W. O.

Cell/surface interactions and adhesion on Ti-6Al-AV: Effects of surface texture. J. Biomed. Mater. Res. B, Appl. Biomater. 2007 82, 360–373

45.

Feinberg

A. W.

Wilkerson

W. R.

Seegert

C. A.

Gibson

A. L.

Hoipkemeier-Wilson

Brennan

A. B.

Systematic variation of microtopography, surface chemistry and elastic modulus and the state dependent effect on endothelial cell alignment. J. Biomed. Mater. Res. A 2008 86, 522–534

46.

Naji

Harmand

M. F.

Study of the effect of the surface state on the cytocompatibility of a Co-Cr alloy using human osteoblasts and fibroblasts. J. Biomed. Mater. Res. 1990 24, 861–871

47.

Martin

J. Y.

Schwartz

Hummert

T. W.

Schraub

D. M.

Simpson

Lankford

Dean

D. D.

Cochran

D. L.

Boyan

B. D.

Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63). J. Biomed. Mater. Res. 1995 29, 389–401

48.

Nishimura

Kawai

Effect of microstructure of titanium surface on the behaviour of osteogenic cell line MC3T3-E1. J. Mater. Sci., Mater. Med. 1998 9, 99–102

49.

Gadelmawla

E. S.

Koura

M. M.

Maksoud

T. M. A.

Elewa

I. M.

Soliman

H. H.

Roughness parameters. J. Mater. Process. Technol. 2002 123, 133–145

50.

MacDonald

Campbell

Fisher

Wennerberg

Variation in surface texture measurements. J. Biomed. Mater. Res. B, Appl. Biomater. 2004 70, 262–269

51.

Anselme

Bigerelle

Topography effects of pure titanium substrates on human osteoblast long-term adhesion. Acta Biomater. 2005 1, 211–222

52.

Kieswetter

Schwartz

Hummert

T. W.

Cochran

D. L.

Simpson

Dean

D. D.

Boyan

B. D.

Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG-63 cells. J. Biomed. Mater. Res. 1996 32, 55–63

53.

Links

Boyan

B. D.

Blanchard

C. R.

Lohmann

C. H.

Liu

Cochran

D. L.

Dean

D. D.

Schwartz

Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. Biomaterials 1998 19, 2219–2232

54.

Deligianni

D. D.

Katsala

N. D.

Koutsoukos

P. G.

Missirlis

Y. F.

Effect of surface roughness of hydroxyapatite on human bone marrow cell adhesion, proliferation, differentiation and detachment strength. Biomaterials 2001 22, 87–96

55.

Deligianni

D. D.

Katsala

Ladas

Sotiropoulou

Amedee

Missirlis

Y. F.

Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption. Biomaterials 2001 22, 1241–1251

56.

Mustafa

Wennerberg

Wroblewski

Hultenby

Silva Lopez

Arvidson

Determining optimal surface roughness of TiO₂ blasted titanium implant material for attachment, proliferation and differentiation of cells derived from human mandibular alveolar bone. Clin. Oral Implant Res. 2001 12, 515–525

57.

Brett

P. M.

Harle

Salih

Milhoc

Olsen

Jones

F. H.

Tonetti

Roughness response genes in osteoblasts. Bone 2004 35, 124–133

58.

Postiglione

di Domenico

Ramaglia

di Lauro

A. E.

di Meglio

Montagnani

Different titanium surfaces modulate the bone phenotype of SaOS-2 osteoblast-like cells. Eur. J. Histochem. 2004 49, 213–222

59.

Hamilton

D. W.

Brunette

D. M.

The effect of substratum topography on osteoblast adhesion mediated signal transduction and phosphorylation. Biomaterials 2007 28, 1806–1819

60.

Castellani

de Ruijter

J. E.

Renggli

Jansen

J. A.

Response of rat bone marrow cells to differently roughened titanium discs. Clin. Oral Implant Res. 1999 10, 369–378

61.

Rosa

A. L.

Beloti

M. M.

Rat bone marrow cell response to titanium and titanium alloy with different surface roughness. Clin. Oral Implant Res. 2003 14, 43–48

62.

Setzer

Bachle

Metzger

M. C.

Kohal

R. J.

The gene-expression and phenotypic response of hFOB 1.19 osteoblasts to surface-modified titanium and zirconia. Biomaterials 2009 30, 979–990

63.

Boyan

B. D.

Batzer

Kieswetter

Liu

Cochran

D. L.

Szmuckler-Moncler

Dean

D. D.

Schwartz

Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1α,25-(OH)₂ D₃ . J. Biomed. Mater. Res. 1998 39, 77–85

64.

Lohmann

C. H.

Bonewald

L. F.

Sisk

M. A.

Sylvia

V. L.

Cochran

D. L.

Dean

D. D.

Boyan

B. D.

Schwartz

Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D₃ . J. Bone Miner. Res. 2000 15, 1169–1180

65.

Lohmann

C. H.

Sagun

Sylvia

V. L.

Cochran

D. L.

Dean

D. D.

Boyan

B. D.

Schwartz

Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)₂ D₃ through regulation of phospholipase A₂ activity and activation of protein kinase A. J. Biomed. Mater. Res. 1999 47, 139–151

66.

Lohmann

C. H.

Tandy

E. M.

Sylvia

V. L.

Hell-Vocke

A. K.

Cochran

D. L.

Dean

D. D.

Boyan

B. D.

Schwartz

Response of normal female human osteoblasts (NHOst) to 17β-estradiol is modulated by implant surface morphology. J. Biomed.Mater. Res. 2002 62, 204–213

67.

Boyan

B. D.

Lossdörfer

Wang

Zhao

Lohmann

C. H.

Cochran

D. L.

Schwartz

Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur. Cells Mater. 2003 6, 22–27

68.

Schwartz

Olivares-Navarrete

Wieland

Cochran

D. L.

Boyan

B. D.

Mechanisms regulating increased production of osteoprotegerin by osteoblasts cultured on microstructured titanium surfaces. Biomaterials 2009 30, 3390–3396

69.

Boyan

B. D.

Sylvia

V. L.

Liu

Sagun

Cochran

D. L.

Lohmann

C. H.

Dean

D. D.

Schwartz

Surface roughness mediates its effects on osteoblasts via protein kinase A and phospholipase A₂ . Biomaterials 1999 20, 2305–2310

70.

Schwartz

Lohmann

C. H.

Sisk

M. A.

Cochran

D. L.

Sylvia

V. L.

Simpson

Dean

D. D.

Boyan

Local factor production by MG63 osteoblast-like cells in response to surface roughness and 1,25-(OH)₂ D₃ is mediated via protein kinase C- and protein kinase A-dependent pathways. Biomaterials 2001 22, 731–741

71.

Wang

Zhao

Olivares-Navarrete

Bell

B. F.

Wieland

Cochran

D. L.

Schwartz

Boyan

B. D.

Integrin β1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxyvitamin D3. Biomaterials 2006 27, 3716–3725

72.

Keselowsky

B. G.

Wang

Schwartz

Garcia

A. J.

Boyan

B. D.

Integrin α5 controls osteoblastic proliferation and differentiation responses to titanium substrates presenting different roughness characteristics in a roughness independent manner. J. Biomed. Mater. Res. A 2007 80, 700–710

73.

Olivares-Navarrete

Raz

Zhao

Chen

Wieland

Cochran

D. L.

Chaudhri

R. A.

Ornoy

Boyan

B. D.

Schwartz

Integrin alpha2beta1 plays a critical role in osteoblast response to micron-scale surface structure and surface energy of titanium substrates. Proc. Natl. Acad. Sci. USA 2008 105, 15,767–15,772

74.

Sinha

R. K.

Tuan

R. S.

Regulation of human osteoblast integrin expression by orthopedic implant materials. Bone 1996 18, 451–457

75.

Nebe

Lüthen

Baumann

Beck

Diener

Neumann

H.-G.

Rychly

Effects of titanium surface topography on the cell-extracellular matrix interaction in osteoblasts. Mater. Sci. Forum 2003 426–432, 3023–3030

76.

Lüthen

Lange

Becker

Rychly

Beck

Nebe

The influence of surface roughness of titanium on β1 and β3-integrin adhesion and the organization of fibronectin in human osteoblastic cells. Biomaterials 2005 15, 2423–2440

77.

Lange

Lüthen

Beck

Rychly

Baumann

Nebe

Cell-extracellular matrix interaction and physico-chemical characteristics of titanium surfaces depend on the roughness of the material. Biomol. Engng 2002 19, 255–261

78.

Jayaraman

Meyer

Bühner

Joos

Wiesmann

H.-P.

Influence of titanium surfaces on attachment of osteoblast-like cells in vitro . Biomaterials 2003 25, 625–631

79.

Leng

Quantitative analysis of osteoblast behavior on microgrooved hydroxyapatite and titanium substrata. J. Biomed. Mater. Res. A 2002 66, 677–687

80.

Anselme

Bigerelle

Noël

Loison

Hardouin

Kinetic study of the expression of β-catenin, actin and vinculin during osteoblastic adhesion on grooved titanium substrates. Biomed. Mater. Engng 2004 14, 545–556

81.

Ismail

F. S. M.

Rohanizadeh

Atwa

Mason

R. S.

Ruys

A. J.

Martin

P. J.

Bendavid

The influence of surface chemistry and topography on the contact guidance of MG63 osteoblast cells. J. Mater. Sci., Mater. Med. 2007 18, 705–714

82.

Anselme

Bigerelle

Noël

Iost

Hardouin

Effect of grooved titanium substratum on human osteoblastic cell growth. J. Biomed. Mater. Res. 2002 60, 529–540

83.

Bigerelle

Anselme

Noël

Ruderman

Hardouin

Iost

Improvement in the morphology of surfaces for cell adhesion: A new process to double human osteoblast adhesion on Ti-based substrates. Biomaterials 2002 23, 1563–1577

84.

Kunzler

T. P.

Drobek

Schuler

Spencer

N. D.

Systematic study of osteoblast and fibroblast response to roughness by means of surface-morphology gradients. Biomaterials 2007 28, 2175–2182

85.

Dalby

M. J.

Riehle

M. O.

Sutherland

D. S.

Agheli

Curtis

A. S.

Fibroblast response to a controlled nanoenvironment produced by colloidal lithography. J. Biomed. Mater. Res. A 2004 69, 314–322

86.

Andersson

A. S.

Brink

Lidberg

Sutherland

D. S.

Influence of systematically varied nanoscale topography on the morphology of epithelial cells. IEEE Trans. Nanobiosci. 2003 2, 49–57

87.

Dalby

M. J.

Gadegaard

Riehle

M. O.

Wilkinson

C. D.

Curtis

A. S.

Investigating filopodia sensing using arrays of defined nano-pits down to 35 nm diameter in size. Int. J. Biochem. Cell Biol. 2004 36, 2005–2015

88.

Loesberg

W. A.

te Riet

van Delft

F. C.

Schon

Figdor

C. G.

Speller

van Loon

J. J.

Walboomers

X. F.

Jansen

J. A.

The threshold at which substrate nanogroove dimensions may influence fibroblast alignment and adhesion. Biomaterials 2007 28, 3944–3951

89.

Walter

Selhuber

Kessler

Spatz

J. P.

Cellular unbinding forces of initial adhesion processes on nanopatterned surfaces probed with magnetic tweezers. Nano Lett. 2006 6, 398–402

90.

Cavalcanti-Adam

E. A.

Micoulet

Blümmel

Auernheimer

Kessler

Spatz

J. P.

Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly. Eur. J. Cell Biol. 2006 85, 219–224

91.

Arnold

Hirschfeld-Warneken

V. C.

Lohmuller

Heil

Blummel

Cavalcanti-Adam

E. A.

Lopez-Garcia

Walther

Kessler

Geiger

Spatz

J. P.

Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing. Nano Lett. 2008 8, 2063–2069

92.

Dalby

M. J.

Pasqui

Affrossman

Cell response to nano-islands produced by polymer demixing: A brief review. IEE Proc. Nanobiotechnol. 2004 151, 53–61

93.

Dalby

M. J.

Riehle

M. O.

Johnstone

Affrossman

Curtis

A. S.

Investigating the limits of filopodial sensing: A brief report using SEM to image the interaction between 10 nm high nano-topography and fibroblast filopodia. Cell Biol. Int. 2004 28, 229–236

94.

Lim

J. Y.

Dreiss

A. D.

Zhou

Hansen

J. C.

Siedlecki

C. A.

Hengstebeck

R. W.

Cheng

Winograd

Donahue

H. J.

The regulation of integrin-mediated osteoblast focal adhesion and focal adhesion kinase expression by nanoscale topography. Biomaterials 2007 28, 1787–1797

95.

Swan

E. E. L.

Popat

K. C.

Grimes

C. A.

Desai

T. A.

Fabrication and evaluation of nanoporous alumina membranes for osteoblast culture. J. Biomed. Engng 2005 72, 288–295

96.

Popat

K. C.

Eltgroth

LaTempa

T. J.

Grimes

C. A.

Desai

T. A.

Titania nanotubes: A novel platform for drug-eluting coatings for medical implants?

Small 2007 3, 1878–1881

97.

Popat

K. C.

Chatvanichkul

K. I.

Barnes

G. L.

LaTempa

T. J.

Grimes

C. A.

Desai

T. A.

Osteogenic differentiation of marrow stromal cells cultured on nanoporous alumina surfaces. J. Biomed. Mater. Res. A 2007 80, 955–964

98.

Peng

Eltgroth

M. L.

LaTempa

T. J.

Grimes

C. A.

Desai

T. A.

The effect of TiO₂ nanotubes on endothelial function and smooth muscle proliferation. Biomaterials 2009 30, 1268–1272

99.

Brammer

K. S.

Cobb

C. J.

Bjursten

L. M.

van der Heyde

Jin

Improved bone-forming functionality on diameter-controlled TiO₂ nanotube surface. Acta Biomater. 2009 5, 3215–3223

100.

Brammer

K. S.

Y. S. J.

Teng

Engler

A. J.

Chien

Jin

Stem cell fate dictated solely by altered nanotube dimension. Proc. Natl. Acad. Sci. USA 2009 106, 2130–2135

101.

Zinger

Anselme

Denzer

Habersetzer

Wieland

Jeanfils

Hardouin

Landolt

Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale dependant morphology. Biomaterials 2004 25, 2695–2711

102.

de Oliveira

P. T.

Zalzal

S. F.

Beloti

M. M.

Rosa

A. L.

Nanci

Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J. Biomed. Mater. Res. A 2007 80, 554–564

103.

Liu

Webster

T. J.

Nanomedicine for implants: A review of studies and necessary experimental tools. Biomaterials 2007 28, 354–369

104.

Sato

Webster

T. J.

Nanobiotechnology: Implications for the future of nanotechnology in orthopedic applications. Expert Rev. Med. Dev. 2004 1, 105–114

105.

Colon

Ward

B. C.

Webster

T. J.

Increased osteoblast and decreased staphylococcus epidermidis functions on nanophase ZnO and TiO₂ . J. Biomed. Mater. Res. A 2006 78, 595–604

106.

Webster

T. J.

Ergun

Doremus

R. H.

Siegel

R. W.

Bizios

Enhanced functions of osteoblasts on nanophase ceramics. Biomaterials 2000 21, 1803–1810

107.

Webster

T. J.

Ejiofor

J. U.

Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo. Biomaterials 2004 25, 4730–4739

108.

Balasundaram

Webster

T. J.

Increased osteoblast adhesion on nanograined Ti modified with KRSR. J. Biomed. Mater. Res. A 2007 80, 602–611

109.

Miller

D. C.

Thapa

Haberstroh

K. M.

Webster

T. J.

Endothelial and vascular smooth muscle cell function on poly(lactic-co-glycolic acid) with nano-structured surface features. Biomaterials 2004 25, 53–61

110.

Miller

D. C.

Haberstroh

K. M.

Webster

T. J.

PLGA nanometer surface features manipulate fibronectin interactions for improved vascular cell adhesion. J. Biomed. Mater. Res. A 2007 81, 678–684

111.

Price

R. L.

Waid

M. C.

Haberstroh

K. M.

Webster

T. J.

Selective bone cell adhesion on formulations containing carbon nanofibers. Biomaterials 2003 24, 1877–1887

112.

Price

R. L.

Ellison

Haberstroh

K. M.

Webster

T. J.

Nanometer surface roughness increases select osteoblast adhesion on carbon nanofiber compacts. J. Biomed. Mater. Res. A 2004 70, 129–138

113.

Webster

T. J.

Ergun

Doremus

R. H.

Siegel

R. W.

Bizios

Specific proteins mediate enhanced osteoblast adhesion on nanophase ceramics. J. Biomed. Mater. Res. 2000 51, 475–483

114.

Webster

T. J.

Schadler

L. S.

Siegel

R. W.

Bizios

Mechanisms of enhanced osteoblast adhesion on nanophase alumina involve vitronectin. Tissue Engng 2001 7, 291–301

115.

Mendonca

D. B.

Simoes

L. G.

Araujo

A. L.

Leite

E. R.

Duarte

W. R.

Cooper

L. F.

Aragao

F. J.

Nanostructured alumina-coated implant surface: Effect on osteoblast-related gene expression and bone-to-implant contact in vivo . Int. J. Oral Maxillofac. Impl. 2009 24, 205–215

116.

Meirelles

Ardvisson

Andersson

Kjellin

Albrektsson

Wennerberg

Nano hydroxyapatite structures influence early bone formation. J. Biomed. Mater. Res. A 2008 87, 299–307

117.

Meirelles

Albrektsson

Kjellin

Arvidsson

Franke-Stenport

Andersson

Currie

Wennerberg

Bone reaction to nanohydroxyapatite modified titanium implants placed in a gap-healing model. J. Biomed. Mater. Res. A 2008 87, 624–631

118.

Bigerelle

Anselme

Dufresne

Hardouin

Iost

An unscaled parameter to measure the order of surfaces. A new surface elaboration to increase cells adhesion. Biomol. Engng 2002 19, 79–83

119.

Dalby

M. J.

Gadegaard

Tare

R. S.

Andar

Riehle

M. O.

Herzyk

Wilkinson

C. D. W.

Oreffo

R. O. C.

The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nat. Mater. 2007 6, 997–1003

120.

Hamilton

D. W.

Chehroudi

Brunette

D. M.

Comparative response of epithelial cells and osteoblasts to microfabricated tapered pit topographies in vitro and in vivo . Biomaterials 2007 28, 2281–2293

121.

Cooper

L. F.

A role for surface topography in creating and maintaining bone at titanium endosseous implants. J. Prosthet. Dent. 2000 84, 522–534

122.

Shalabi

M. M.

Gortemaker

Van't Hof

M. A.

Jansen

J. A.

Creugers

N. H.

Implant surface roughness and bone healing: A systematic review. J. Dent. Res. 2006 85, 496–500

123.

Göransson

Wennerberg

Bone formation at titanium implants prepared with iso- and anisotropic surfaces of similar roughness: An in vivo study. Clin. Implant Dent. Res. 2005 7, 17–23

124.

Keselowsky

B. G.

Collard

D. M.

Garcia

A. J.

Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc. Natl. Acad. Sci. USA 2005 102, 5953–5957

125.

Barbosa

J. N.

Madureira

Barbosa

M. A.

Aguas

A. P.

The influence of functional groups of self-assembled monolayers on fibrous capsule formation and cell recruitment. J. Biomed. Mater. Res. A 2006 76, 737–743

126.

Lim

J. Y.

Liu

Vogler

E. A.

Donahue

H. J.

Systematic variation in osteoblast adhesion and phenotype with substratum surface characteristics. J. Biomed. Mater. Res. A 2004 68, 504–512

127.

Zelzer

Majani

Bradley

J. W.

Rose

F. R.

Davies

M. C.

Alexander

M. R.

Investigation of cell–surface interactions using chemical gradients formed from plasma polymers. Biomaterials 2008 29, 172–184

128.

Schakenraad

J. M.

Busscher

H. J.

Wildevuur

C. R. H.

Arends

The influence of substratum surface free energy on growth and spreading of human fibroblasts in the presence and absence of serum proteins. J. Biomed. Mater. Res. 1986 20, 773–784

129.

Möller

Meyer

Szulczewski

D. H.

Heide

Priessnitz

Jones

D. B.

The influence of zeta potential and interfacial tension on osteoblast-like cells. Cells Mater. 1994 4, 263–274

130.

Hunter

Archer

C. W.

Walker

P. S.

Blunn

G. W.

Attachment and proliferation of osteoblasts and fibroblasts on biomaterials for orthopaedic use. Biomaterials 1995 16, 287–295

131.

Howlett

C. R.

Zreiqat

McFall

D. W.

McKenzie

D. R.

Effect of ion modification of commonly used orthopedic materials on the attachment of human bone-derived cells. J. Biomed. Mater. Res. 1999 45, 345–354

132.

Zreiqat

Evans

Howlett

C. R.

Effect of surface chemical modification of bioceramic on phenotype of human-bone derived cells. J. Biomed. Mater. Res. 1999 44, 389–396

133.

Zreiqat

Valenzuela

S. M.

Nissan

B. B.

Roest

Knabe

Radlanski

R. J.

Renz

Evans

P. J.

The effect of surface chemistry modification of titanium alloy on signalling pathways in human osteoblasts. Biomaterials 2005 26, 7579–7586

134.

Liu

Lim

J. Y.

Donahue

H. J.

Dhurjati

Mastro

A. M.

Vogler

E. A.

Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro . Biomaterials 2007 28, 4535–4550

135.

Baier

R. E.

Meyer

A. E.

Natiella

J. R.

Natiella

R. R.

Carter

J. M.

Surface properties determine bioadhesive outcomes: Methods and results. J. Biomed. Mater. Res. 1984 18, 337–355

136.

Ferguson

S. J.

Broggini

Wieland

de Wild

Rupp

Geis-Gerstorfer

Cochran

D. L.

Buser

Biomechanical evaluation of the interfacial strength of a chemically modified sandblasted and acid-etched titanium surface. J. Biomed. Mater. Res. A 2006 78, 291–297

137.

F. M.

Yang

G. L.

Y. N.

Wang

X. X.

Zhao

S. F.

Early bone response to sandblasted, dual acid-etched and H₂ O₂/HCl treated titanium implants: An experimental study in the rabbit. Int. J. Oral Maxillofac. Surg. 2009 38, 677–681

138.

Kim

Choi

S. H.

Ryu

J. J.

Koh

S. Y.

Park

J. H.

Lee

I. S.

The biocompatibility of SLA-treated titanium implants. Biomed. Mater. Engng 2008 3, 1–6

139.

Sul

Y.-T.

Johansson

C. B.

Kang

Jeon

D.-G.

Albrektsson

Bone reactions to oxidized titanium implants with electrochemical anion sulphuric acid and phosphoric acid incorporation. Clin. Implant Dent. Res. 2002 4, 78–87

140.

Sul

Y.-T.

Johansson

C. B.

Röser

Albrektsson

Qualitative and quantitative observations of bone tissue reactions to anodised implants. Biomaterials 2002 23, 1809–1817

141.

Sul

Y. T.

Kang

B. S.

Johansson

H. S.

Park

C. J.

Albrektsson

The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone. J. Biomed. Mater. Res. A 2009 89, 942–950

142.

Aita

Att

Ueno

Yamada

Hori

Iwasa

Tsukimura

Ogawa

Ultraviolet light-mediated photofunctionalization of titanium to promote human mesenchymal stem cell migration, attachment, proliferation and differentiation. Acta Biomater. 2009 5, 3247–3257

143.

Aita

Hori

Takeuchi

Suzuki

Yamada

Anpo

Ogawa

The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials 2009 30, 1015–1025

144.

Braceras

de Maeztu

M. A.

Alava

J. I.

Gay-Escoda

In vivo low-density bone apposition on different implant surface materials. Int. J. Oral Maxillofac. Surg. 2009 38, 274–278

145.

Sul

Y.-T.

Johansson

C. B.

Albrektsson

Oxidized titanium screws coated with calcium ions and their performance in rabbit bone. Int. J. Oral Maxillofac. Impl. 2002 17, 625–634

146.

Buser

Broggini

Wieland

Schenk

R. K.

Denzer

A. J.

Cochran

D. L.

Hoffmann

Lussi

Steinemann

S. G.

Enhanced bone apposition to a chemically modified SLA titanium surface. J. Dent. Res. 2004 83, 529–533

147.

Cochran

D. L.

Buser

ten Bruggenkate

C. M.

Weingart

Taylor

T. M.

Bernard

J. P.

Peters

Simpson

J. P.

The use of reduced healing times on ITI implants with a sandblasted and acid-etched (SLA) surface: Early results from clinical trials on ITI SLA implants. Clin. Oral Implant Res. 2002 13, 144–153

148.

Bornstein

M. M.

Schmid

Belser

U. C.

Lussi

Buser

Early loading of non-submerged titanium implants with a sandblasted and acid-etched surface. 5-year results of a prospective study in partially edentulous patients. Clin. Oral Implant Res. 2005 16, 631–638

149.

Rupp

Scheideler

Olshanska

de Wild

Wieland

Geis-Gerstorfer

Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J. Biomed. Mater. Res. A 2006 76, 323–334

150.

Zhao

Schwartz

Wieland

Rupp

Geis-Gerstorfer

Cochran

D. L.

Boyan

B. D.

High surface energy enhances cell response to titanium substrate microstructure. J. Biomed. Mater. Res. A 2005 74, 49–58

151.

Zhao

Raines

A. L.

Wieland

Schwartz

Boyan

B. D.

Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography. Biomaterials 2007 28, 2821–2829

152.

Schatzle

Mannchen

Balbach

Hammerle

C. H.

Toutenburg

Jung

R. E.

Stability change of chemically modified sandblasted/acid-etched titanium palatal implants. A randomized-controlled clinical trial. Clin. Oral Implant Res. 2009 20, 489–495

153.

Schwarz

Wieland

Schwartz

Zhao

Rupp

Geis-Gerstorfer

Schedle

Broggini

Bornstein

M. M.

Buser

Ferguson

S. J.

Becker

Boyan

B. D.

Cochran

D. L.

Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. J. Biomed. Mater. Res. B, Appl. Biomater. 2009 88, 544–557

154.

Wilson

C. J.

Clegg

R. E.

Leavesley

D. I.

Pearcy

M. J.

Mediation of biomaterial–cell interactions by adsorbed proteins: A review. Tissue Engng 2005 11, 1–18

155.

Lee

M. H.

Ducheyne

Lynch

Boettiger

Composto

Effect of biomaterial surface properties on fibronectin-α5β1 integrin interaction and cellular attachment. Biomaterials 2006 27, 1907–1916

156.

Baujard-Lamotte

Noinville

Goubard

Marque

Pauthe

Kinetics of conformational changes of fibronectin adsorbed onto model surfaces. Colloid Surf. B, Biointerfaces 2008 63, 129–137

157.

Iuliano

D. J.

Saavedra

S. S.

Truskey

G. A.

Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion. J. Biomed. Mater. Res. 1993 27, 1103–1113

158.

Faucheux

Schweiss

Lützow

Werner

Groth

Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies. Biomaterials 2004 25, 2721–2730

159.

Rodrigues

S. N.

Gonçalves

I. C.

Martins

M. C. L.

Barbosa

M. A.

Ratner

B. D.

Fibrinogen adsorption, platelet adhesion and activation on mixed hydroxyl-/methyl-terminated self-assembled monolayers. Biomaterials 2006 27, 5357–5367

160.

Scotchford

C. A.

Gilmore

C. P.

Cooper

Leggett

G. J.

Downes

Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers. J. Biomed. Mater. Res. 2002 59, 84–99

161.

Uyen

H. M. W.

Schakenraad

J. M.

Sjollema

Noordmans

Jongebloed

W. L.

Stokroos

Busscher

H. J.

Amount and surface structure of albumin adsorbed to solid substrata with different wettabilities in a parallel plate flow chamber. J. Biomed. Mater. Res. 1990 24, 1599–1614

162.

Kilpadi

K. L.

Chang

P. L.

Bellis

S. L.

Hydroxylapatite binds more serum proteins, purified integrins, and osteoblast precursor cells than titanium or steel. J. Biomed. Mater. Res. 2001 57, 258–267

163.

Ducheyne

Qiu

Bioactive ceramics: The effect of surface reactivity on bone formation and bone cell function. Biomaterials 1999 20, 2287–2303

164.

Davies

J. E.

Bone bonding at natural and biomaterial surfaces. Biomaterials 2007 28, 5058–5067

165.

Ripamonti

Osteoinduction in porous hydroxyapatite implanted in heterotopic sites of different animal models. Biomaterials 1996 17, 31–35

166.

Yuan

Zou

Yang

Zhang

de Bruijn

J. D.

de Groot

Bone morphogenetic protein and ceramic-induced osteogenesis. J. Mater. Sci., Mater. Med. 1998 9, 717–721

167.

Yuan

Yang

Zhang

de Bruijn

J. D.

de Groot

Osteoinduction by calcium phosphate biomaterials. J. Mater. Sci., Mater. Med. 1998 9, 723–726

168.

Habibovic

Yuan

van der Valk

C. M.

Meijer

van Blitterswijk

C. A.

de Groot

3D microenvironment as essential element for osteoinduction by biomaterials. Biomaterials 2005 26, 3565–3576

169.

Pegueroles

Aparicio

Bosio

Engel

Gil

F. J.

Planell

J. A.

Altankov

Spatial organization of osteoblast fibronectin matrix on titanium surfaces: Effects of roughness, chemical heterogeneity and surface energy. Acta Biomater. 2010 6, 291–301

170.

Morra

Cassinelli

Cascardo

Cahalan

Fini

Giardino

Surface engineering of titanium by collagen immobilization. Surface characterization and in vitro and in vivo studies. Biomaterials 2003 24, 4639–4654

171.

Morra

Cassinelli

Cascardo

Mazzucco

Borzini

Fini

Giavaresi

Giardino

Collagen I-coated titanium surfaces: Mesenchymal cell adhesion and in vivo evaluation in trabecular bone implants. J. Biomed. Mater. Res. A 2006 78, 449–458

172.

Reyes

C. D.

Petrie

T. A.

Burns

K. L.

Schwartz

Garcia

A. J.

Biomolecular surface coating to enhance orthopaedic tissue healing and integration. Biomaterials 2007 28, 3228–3235

173.

Petrie

T. A.

Raynor

J. E.

Reyes

C. D.

Burns

K. L.

Collard

D. M.

Garcia

A. J.

The effect of integrin specific bioactive coatings on tissue healing and implant osseointegration. Biomaterials 2008 29, 2849–2857

174.

Kroese-Deutman

H. C.

van den Dolder

Spauwen

P. H.

Jansen

J. A.

Influence of RGD-loaded titanium implants on bone formation in vivo . Tissue Engng 2005 11, 1867–1875

175.

Elmengaard

Bechtlod

J. E.

Soballe

In vivo study of the effect of RGD treatment on bone ongrowth on press-fit titanium alloy implants. Biomaterials 2005 26, 3521–3526

176.

Ferris

D. M.

Moodie

G. D.

Dimond

P. M.

Gioranni

C. W. D.

Ehrlich

M. G.

Valentini

R. F.

RGD-coated titanium implants stimulate increased bone formation in vivo . Biomaterials 1999 20, 2323–2331

177.

Dard

Sewing

Meyer

Verrier

Roessler

Scharnweber

Tools for tissue engineering of mineralized oral structures. Clin. Oral Invest. 2000 4, 126–129

178.

Rammelt

Illert

Bierbaum

Scharnweber

Zwipp

Schneiders

Coating of titanium implants with collagen, RGD peptide and chondroitin sulfate. Biomaterials 2006 27, 5561–5571

179.

Bernhardt

van den Dolder

Bierbaum

Beutner

Schwarnweber

Jansen

J. A.

Beckmann

Worch

Osteoconductive modifications of Ti-implants in a goat defect model: Characterization of bone growth with SR μCT and histology. Biomaterials 2005 26, 3009–3019

180.

Bitschnau

Alt

Böhner

Heerich

K. E.

Margesin

Hartman

Sewing

Meyer

Wenisch

Schnettler

Comparison of new bone formation, implant integration and biocompatibility between RGD hydroxyapatite and pure hydroxyapatite coating for cementless joint protheses. An experimental study in rabbits. J. Biomed. Mater. Res. B, Appl. Biomater. 2009 88, 66–74

181.

Hennessy

K. M.

Clem

W. C.

Phipps

M. C.

Sawyer

A. A.

Shaikh

F. M.

Bellis

S. L.

The effect of RGD peptides on osseointegration of hydroxyapatite biomaterials. Biomaterials 2008 29, 3075–3083

182.

Britland

Morgan

WojiakStodart

Riehle

Curtis

Wilkinson

Synergistic and hierarchical adhesive and topographic guidance of BHK cells. Exp. Cell Res. 1996 228, 313–325

183.

Nebe

J. G.

Luethen

Lange

Beck

Interface interactions of osteoblasts with structured titanium and the correlation between physicochemical characteristics and cell biological parameters. Macromol. Biosci. 2007 7, 567–578

184.

Anselme

Bigerelle

Effect of a gold-palladium coating on the long-term adhesion of human osteoblasts on biocompatible metallic materials. Surf. Coat. Technol. 2006 200, 6325–6330

185.

Bigerelle

Anselme

Statistical correlation between cell adhesion and proliferation on biocompatible materials. J. Biomed. Mater. Res. A 2005 72, 36–46

Relative influence of surface topography and surface chemistry on cell response to bone implant materials. Part 2: Biological aspects

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