The collision induced dissociation and electron induced dissociation spectra of the [2M + H]+ and [2M + Na]+ clusters of the zwitterionic amino acid, betaine (M), have been examined in a hybrid linear ion trap Fourier transform ion cyclotron resonance mass spectrometer. Intercluster reactions are observed in the collision induced dissociation spectra of [2M + H]+ and [2M + Na]+ and in the electron induced dissociation spectrum of [2M + H]+.
CodyR.B.FreiserB.S., “Electron impact excitation of ions from organics: An alternative to collision induced dissociation”, Anal. Chem.51, 547 (1979). doi: 10.1021/ac50040a022
2.
OhashiM.BarronR.P.BensonW.R., “Electron-impact-induced fragmentation of quaternary ammonium cations”, J. Am. Chem. Soc.103, 3943 (1981). doi: 10.1021/ja00403a064
3.
WangB.H.McLaffertyF.W., “Electron-impact excitation of ions from larger organic molecules”, Org. Mass Spectrom.25, 554 (1990). doi: 10.1002/oms.1210251012
4.
AberthW.BurlingameA.L., “Electron collision induced dissociation (El CID) applied to mass spectrometry”, Biol. Mass Spectrom., Proc. Int. Symp. Mass Spectrom. Health Life Sci., Ed by BurlingameA.L.McCloskeyJ. A., Elsevier, Amsterdam, p. 217 (1990).
5.
(a) ZubarevR.A., “Reactions of polypeptide ions with electrons in the gas phase”, Mass Spectrom. Rev.22, 57 (2003). doi: 10.1002/mas.10042; (b) CooperH.J.HakanssonK.MarshallA.G., “The role of electron capture dissociation in biomolecular analysis”, Mass Spectrom. Rev.24, 201 (2005). doi: 10.1002/mas.20014; (c) ZubarevR.A.HaselmannK.F.BudnikB.KjeldsenF.JensenF., “Towards an understanding of the mechanism of electron-capture dissociation: A historical perspective and modern ideas”, Eur. J. Mass. Spectrom.8, 337 (2002). doi: 10.1255/ejms.517
6.
(a) MalekR.Metelmann-StrupatW.ZellerM.MuensterH., “Electron capture dissociation on a hybrid linear ion trap/FTICR mass spectrometer”, Am. Biotech. Lab.23, 8 (2005); (b) MarshallA.G.HendricksonC.L.ErnmettaM.R.RodgersR.P.BlakneyG.T.NilssonC.L., “Fourier transform ion cyclotron resonance: State of the art”, Eur. J. Mass. Spectrom.13, 57 (2007). doi: 10.1255/ejms.846; (c) RomppA.TabanI.M.MihalcaR.DuursmaM.C.MizeT.H.McDonnellL.A.HeerenR.M.A., “Examples of Fourier transform ion cyclotron resonance mass spectrometry developments: From ion physics to remote access biochemical mass spectrometry”, Eur. J. Mass. Spectrom.11, 443 (2005). doi: 10.1255/ejms.732
7.
YooH.J.LiuH.HakanssonK., “Infrared multiphoton dissociation and electron-induced dissociation as alternative MS/MS strategies for metabolite identification”, Anal. Chem.79, 7858 (2007). doi: 10.1021/ac071139w
8.
KhairallahG.N.O'HairR.A.J.BruceM.I., “Gas-phase synthesis and reactivity studies of binuclear gold hydride cations, (R3PAu)2H+ (R=Me and Ph)”, Dalton Trans.3699 (2006). doi: 10.1039/b604404b
9.
LioeH.O'HairR.A.J., “Comparison of collision induced dissociation and electron induced dissociation of singly protonated aromatic amino acids, cystine and related simple peptides using a hybrid linear ion trap–FT-ICR”, Anal. Bioanal. Chem.389, 1429 (2007). doi: 10.1007/s00216-007-1535-1
10.
HorningS.MalekR.WieghausA.SenkoM.W.SykaJ.E.P., “A hybrid two-dimensional quadrupole ion trap/Fourier transform ion cyclotron mass spectrometer: Accurate mass and high resolution at a chromatography timescale”, Proceedings of the 51st ASMS conference mass spectrometry and allied topics, Montreal (2003).
11.
JamesP.F.PeruginiM.A.O'HairR.A.J., “Sources of artefacts in the electrospray ionization mass spectra of saturated diacylglycerophosphocholines: From condensed phase hydrolysis reactions through to gas phase intercluster reactions”, J. Am. Soc. Mass Spectrom.17, 384 (2006). doi: 10.1016/j.jasms.2005.11.009
12.
PatrickJ.S.YangS.S.CooksR.G., “Determination of the gas-phase basicity of betaine and related compounds using the kinetic method”, J. Am. Chem. Soc.118, 231 (1996). doi: 10.1021/ja9521177
13.
PriceW.D.JockuschR.A.WilliamsE.R., “Binding energies of protonated betaine complexes: A probe of zwitterion structure in the gas phase”, J. Am. Chem. Soc.120, 3474 (1998). doi: 10.1021/ja972527q
14.
CoxH.A.HodyssR.BeauchampJ.L., “Clusterphase reactions: Gas-phase phosphorylation of peptides and model compounds with triphosphate anions”, J. Am. Chem. Soc.127, 4084 (2005). doi: 10.1021/ja0452673
15.
RenD.PolceM.J.WesdemiotisC., “Structural determinants for the evaporation of intact oligomers from collisionally activated cluster ions”, Int. J. Mass Spectrom.228, 933 (2003). doi: 10.1016/S1387-3806(03)00194-5
16.
O'HairR.A.J.WatersT.CaoB., “Sixty years after Wittig: Gas phase synthesis of lithiumtrimethylammonium methylide, [(CH3)3NCH2Li]+”, Angew. Chem. Int. Ed.46, 7048 (2007). doi: 10.1002/anie.200701972
17.
HorspoolW.A., “Photolysis of carbonyl compounds”, Photochem.35, 1 (2004). doi: 10.1039/9781847554840-00001