A Critical Evaluation of the Therapeutic Range of Indinavir

Abstract

OBJECTIVE:

To provide a summary of the patient population, study characteristics, and important findings of the key studies in the literature evaluating concentration—effect relationships and the therapeutic range for indinavir.

DATA SOURCES:

Literature search strategy involved using MEDLINE (1966–July 2001) and AIDSLINE (MEDSCAPE) databases (up to July 2001). Reference lists from primary literature and review articles were also examined, and conference abstracts were obtained.

STUDY SELECTION:

English-language articles were considered suitable for review if the clinical trials in HIV patients reported on concentration—effect relationships and/or pharmacokinetic breakpoints or threshold concentrations. A search of the literature identified 20 peer-reviewed references from 18 separate studies including journal articles and conference abstracts.

DATA EXTRACTION:

The targeted pharmacokinetic parameters and breakpoint values, the rationale for their selection or method of identification, and other study details and limitations were summarized.

DISCUSSION:

This article highlights the heterogeneity of studies evaluating the therapeutic range of indinavir and provides a summary of important findings of the key studies in the literature evaluating concentration-effect relationships and therapeutic range. Tables are provided to enable clinicians to make use of currently available information on the therapeutic range of indinavir.

CONCLUSIONS:

There is insufficient evidence to recommend a general therapeutic range for indinavir. Future investigations should incorporate both pharmacokinetics and pharmacodynamics in order to define a broadly applicable therapeutic range.