Abstract
A photothermal deflection detector for microbore liquid chromatography is described. The detection limit of the system under isocratic flow conditions is shown to be 8 × 10−8 absorbance units. This corresponds to 500 fg of analyte (acid sulfonate rug dye) injected on the column. The detection system is shown to be amenable to gradient elution and open tubular chromatography.
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References
1.
Bradley
A. B.
and
Zare
R. N.
, J. Am. Chem. Soc. 98 , 620 (1976 ).
2.
Woodruff
S. D.
and
Yeung
E. S.
, Anal. Chem. 54 , 1174 (1982 ).
3.
Long
M. E.
Swofford
R. L.
, and
Albrecht
A. C.
, Science 191 , 183 (1976 ).
4.
Mori
K.
Imasaka
T.
, and
Ishibashi
N.
, Anal. Chem. 54 , 2034 (1982 ).
5.
Buffett
C. E.
and
Morris
M. D.
, Anal. Chem. 54 , 1824 (1982 ).
6.
Buffett
C. E.
and
Morris
M. D.
, Anal. Chem. 55 , 376 (1983 ).
7.
Sepaniak
M. J.
Vargo
J. D.
Kettler
C. N.
, and
Maskarinec
M. P.
, Anal. Chem. 56 , 1252 (1984 ).
8.
Peck
K.
Fotiou
F. K.
, and
Morris
M. D.
, Anal. Chem. 57 , 1359 (1985 ).
9.
Boccara
A. C.
Fournier
D.
, and
Badoz
J.
, Appl. Phys. Lett. 36 , 130 (1980 ).
10.
Olmstead
M. A.
Amer
N. M.
, and
Kohn
S.
, Appl. Phys. 32 , 141 (1983 ).
11.
Boccara
A. C.
Fournier
D.
Jackson
W.
, and
Amer
N. M.
, Opt. Lett. 5 , 377 (1980 ).
12.
Fournier
D.
Boccara
A. C.
Amer
N. M.
, and
Gerlach
R.
, Appl. Phys. Lett. 37 , 519 (1980 ).
13.
Jackson
W. B.
Amer
N. M.
Boccara
A. C.
, and
Fournier
D.
, Appl. Opt. 20 , 1333 (1981 ).
14.
Scott
R. P. W.
and
Kucera
P.
, J. Chromatogr. 169 , 51 (1979 ).
15.
Novotny
M.
, J. Chromatogr. Sci. 18 , 473 (1980 ).
16.
Klee
M. S.
Rogers
L. B.
Carreira
L. A.
, and
Azarraga
L.
, Anal. Tech. Envir. Chem. 2 , 177 (1982 ).
17.
Powley
C. R.
Howard
W. A.
, and
Rogers
L. B.
, J. Chromatogr. 299 , 43 (1984 ).
18.
Harris
J. M.
and
Dovichi
N. J.
, Anal. Chem. 52 , 695A (1980 ).
19.
Buffett
C. E.
and
Morris
M. D.
, Appl. Spectrosc. 37 , 455 (1983 ).