Endogenous opioid peptides have been shown to increase in heat stroke attacks and it has been suggested that they are involved in thermoregulation. The aim of the present investigation is to study the effect of naloxone pretreatment on the development of heat stroke in a sheep model. We observe that naloxone decreases the extent of heat stroke signs and some of the induced changes in enzymes and hormones. These observations indicate that naloxone may be a valuable drug in the prevention of heat stroke attacks in susceptible individuals.
AppenzellerO.KhogaliM.CarrD.B.GumaaK.MustafaM.K.Y.JamjoomA.SkipperB.Makkah Hajj: heat stroke and endocrine responses. Ann Sports Med1986; 3, 30–32
2.
AryM.LomaxP.Influence of narcotic agents on temperature regulation. Adv Biochem Psychopharmac1979; 20, 429–451
3.
ClarkW.G.Effects of opioid peptides on thermoregulation. Fed Proc1981; 40, 2754–2759
4.
MartinW.R.Naloxone. Ann Intern Med1976; 85, 765–768
5.
SiramS.ParkS.Naloxone in septic shock: report of two cases. J Nat Med Assoc1984; 76, 713–716
6.
BentonE.W.Naloxone and TRH in the treatment of shock and trauma. What future roles?. Ann Emerg Med1985; 14, 729–735
7.
PaciorekP.M.ToddM.H.WaterfallJ.F.The effects of meptazinol in comparison with pentazocine, morphine and naloxone in a rat model of anaphylactic shock. Br J Pharmacol1985; 84, 469–475
8.
BarsanW.G.HedgesJ.R.SyverudS.A.Hemodynamic effects of naloxone in anaphylactic shock. Resuscitation1986; 13, 223–231
9.
DemeirleirK.ArentzT.HollmannW.The role of endorgenous opiates in thermal regulation of the body during exercise. Brit Med J1985; 290, 739–740
10.
LivingstonA.LowJ.MorrisB.Effects of clonidine and xylazine on body temperature in the rat. Br J Pharmacol1984; 81, 189–193
11.
KhogaliM.ElkhatibG.AttiaM.MustafaM.Y.GummaK.NasrallaA.AldaraniM.S.Induced heat stroke: a model in sheep. In: KhogaliM.HalesJ.R.S. eds. Heat Stroke and Temperature Regulation, Sydney: Academic Press, 1983, 253–262
12.
TayebO.S.MarzoukiZ.M.Tympanic thermometry in heat stroke. Is it justifiable?. Clin Physiol Biochem1989; 7, 255–262
13.
GibaldiM.PerrierD.Trapezoidal rule. In: SwarbrickJ. ed. Drugs and the Pharmaceutical Sciences. Pharmacokinetics, Vol. 1. New York: Marcel Dekker Inc., 1975, 293–296
14.
OufaraS.VeillatJ.P.HelaliE.Survival of acclimatized and hypothyroid rats at 40 degrees. Canad J Physiol1980; 76, 167–171
15.
CarrD.B.BullenB.A.SkrinarG.S.ArnoldM.A.RosenblattM.BeitinsI.Z.MartinJ.B.McArthurJ.W.Physical conditioning facilitate the exercise induced secretion of beta endorphin and beta lipotropin in women. N Engl J Med1981; 305, 560–562
16.
AntonelliT.BeaniL.BianchiC.RandoS.SimonatoM.TanganelliS.Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal. Br J Pharmacol1986; 89, 853–860
17.
WheelerM.Heat stroke in the elderly. Med Clin North Amer1976; 60, 1289–1296