Abstract
Summary
Chromatographic studies reveal the presence of 10 Dragendorff (+) compounds in organic (ethylene dichloride) extracts of alkalinized human urine following administration of chlorpromazine. Six of these compounds appear to be sulfoxides. Included in this group are chlorpromazine sulfoxide — which is a relatively minor product — as well as 2 major metabolites whose chromatographic behavior is indistinguishable from Nor1 and Nor2chlorpromazine sulfoxide. A third major metabolite (compound #4) remains unidentified, but it is not a sulfoxide derivative. It is indicated that the residual urine remaining after extraction contains numerous additional (polar) metabolites.
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