Abstract
Administration of N,N-dimethylacetamide (DMA) terminated pregnancy in hamsters given the compound around nidation (Days 4-5 of pregnancy). DMA was 100% effective at a sc dose of 2.2 g/kg which was, however, about one-third of the lethal dose. This effect was reversible after about 10 days. Oral activity was significant but less effective compared with sc (67% at 2.2 g/kg). Daily injections of progesterone (5 mg/hamster/day—4 consecutive days) blocked the antifertility effect of DMA as did injections of a “luteotropic complex” (1 mg/hamster/day prolactin plus 5.1 IU/hamster day of gonadotropin activity in pregnant mare serum for 4 consecutive days). Microscopic examination of ovarian tissue from DMA-treated hamsters showed extensive degeneration and hemorrhage of corporalutea. The luteotropic complex greatly improved the histological conditions of the ovaries.
