A facile synthetic route for 5-aryl[1,2,4]triazolo[1,5-c]quinazolin-2(3H)-ones and 2(3H)-thiones (3, 4) via 3,1-benzoxazin-4(3H)-ones in good yields under anhydrous conditions has been devised in an effort to develop new bronchodilators for the treatment of asthma.
Part of this work was presented in Scientific Sessions, Medicinal Chemistry Section, 51st Indian Pharmaceutical Congress, held at Indore, India, December 1999. It is taken from the Ph.D thesis of K.S. Rajan, Kakatiya University, Warangal, India (in preparation).
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RaoA.R.R. and BahekarR.H., 3rd International Symposium on Innovation in Pharmaceutical Sciences and Technology, B.V. Patel PERD Centre, Ahmedabad, India, 7–9 Feb. 1997, abstr. no. PP-5.
