The leading peer-reviewed journal in computational biology and bioinformatics, publishing in-depth statistical, mathematical, and computational analysis of methods, as well as their practical impact. The journal publishes articles whose primary contributions are the development and application of new methods in computational biology, including algorithmic, statistical, mathematical, machine learning, and artificial intelligence contributions. The journal welcomes novel methods that tackle established problems within computational biology; novel methods and frameworks that anticipate new problems and data types arising in computational biology; and novel methods that are inspired by studying natural computation. This is an essential journal for scientists and students who want to keep abreast of developments in bioinformatics and computational biology.