This journal is a peer-reviewed venue for promoting and sharing research rooted in hybridoma technology. It aims to advance the understanding of the biology and immunology that underscores the utility of antibodies as diagnostics and therapeutics. Paramount to this aim, the journal scope includes research on the biology of B cells, the production of antibodies in terms of antibody descriptions, antibody engineering innovations, and their use in diagnosis and therapy. Most importantly, the broadened scope includes aspects of biology and immunology at the level of the antibody repertoire, structural biology of the antibody, and modern omics techniques. Methodologically, these areas may include biophysical, biochemical, and computational approaches as well as informatics and database development spanning the computational, genomic, and database resources required for analyses. In the area of diagnosis and therapy, preclinical and clinical assessments of antibodies, and formulations that induce or activate antibodies are welcome.